{"63926":{"#nid":"63926","#data":{"type":"event","title":"Bioengineering Seminar - Sarah Heilshorn, PhD - Stanford University","body":[{"value":"\u003Cp\u003EProtein-based polymeric materials are characterized by\nmulti-functionality, complex structural diversity, and bioactivity.\nUsing protein-based biomaterials may substantially increase the\nefficacy of regenerative medicine therapies by providing cell-protein\ninteractions that guide cell behavior. Several examples of\nprotein-based biomaterials design will be presented to highlight the\nimportance of independent control over biochemical and biomechanical\nproperties. Using recombinant protein technology, we have synthesized\nseveral families of block-co-peptide hydrogels that mimic critical\naspects of the natural extracellular matrix. A modular design strategy\nenables independent tuning of the initial elastic modulus, the density\nof cell adhesion ligands, and the rate of proteolytic remodeling. These\nbiomaterials can be designed to release multiple therapeutic peptides\nwith distinct spatial and temporal delivery profiles. Protein-based\nmaterials can also be used as templates to guide the synthesis of\ninorganic nanomaterials. Specifically, we are utilizing the protein\nclathrin, which has the ability to form multiple 2D and 3D\narchitectures, as a flexible template that can be functionalized at\nspecific sites using designed bi-functional peptides. These peptides\nserve as molecular bridges between binding sites on the clathrin\nprotein and inorganic materials including gold, titania, and cobalt\noxide. By generating a family of engineered peptides, we are developing\na flexible, modular system that will enable the rapid development of\nmultiple inorganic nanostructures from a single protein template\nmaterial.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioengineering Seminar Speaker, Sarah Heilshorn, PhD from Stanford University will be speaking on, \u0022Designing Multi-Functional Biopolymers Through Protein Engineering.\u0022\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Designing Multi-Functional Biopolymers Through Protein Engineering"}],"uid":"27224","created_gmt":"2011-01-27 15:44:22","changed_gmt":"2016-10-08 01:54:00","author":"Megan McDevitt","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2011-02-08T10:00:00-05:00","event_time_end":"2011-02-08T11:00:00-05:00","event_time_end_last":"2011-02-08T11:00:00-05:00","gmt_time_start":"2011-02-08 15:00:00","gmt_time_end":"2011-02-08 16:00:00","gmt_time_end_last":"2011-02-08 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"5983","name":"Bioengineering Seminar"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty Host: Valeria Milam, PhD\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}