{"637426":{"#nid":"637426","#data":{"type":"event","title":"PhD Defense by Tim O\u0027Sullivan","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDoctor of Philosophy in Biology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EIn the\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETim O\u0026rsquo;Sullivan\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWill defend his dissertation\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThe Dynamics of death:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003Edetermining the relationship between within-host pathogen dynamics and host mortality\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETuesday, August 11\u003Csup\u003Eth\u003C\/sup\u003E, 2020\u003C\/p\u003E\r\n\r\n\u003Cp\u003E1:00 PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/bluejeans.com\/373440017\/\u0022\u003Ehttps:\/\/bluejeans.com\/373440017\/\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMeeting ID: 373 440 017\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Sam Brown\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECo-Advisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Kristofer Wollein Waldetoft\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Patrick McGrath\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Steve Diggle\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Nicole Vega\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca name=\u0022_Hlk47004434\u0022\u003EDepartment of Biology\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEmory University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EABSTRACT\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EInfectious diseases remain a major cause of global mortality, yet basic questions concerning the relationship between within-host pathogen processes and epidemiological patterns of mortality remain obscure. First, I develop a conceptual framework to link pathogen dynamics (pathogen burden\u0026nbsp;\u003Cem\u003Ep\u003C\/em\u003E(\u003Cem\u003Et\u003C\/em\u003E)\u0026nbsp;as a function of time since infection\u0026nbsp;\u003Cem\u003Et\u003C\/em\u003E) with instantaneous host mortality\u0026nbsp;\u003Cem\u003Em\u003C\/em\u003E(\u003Cem\u003Et\u003C\/em\u003E), and show that multiple math models are consistent with observed accelerating\u0026nbsp;\u003Cem\u003Em\u003C\/em\u003E(\u003Cem\u003Et\u003C\/em\u003E)\u0026nbsp;infection data, using existing data from multiple experimental infection models.\u0026nbsp; Second, \u0026nbsp;I develop an experimental\u0026nbsp;\u003Cem\u003EC. elegans \/ Pseudomonas aeruginosa\u003C\/em\u003E\u0026nbsp;infection model platform to allow non-invasive tracking of\u0026nbsp;\u003Cem\u003Ep\u003C\/em\u003E(\u003Cem\u003Et\u003C\/em\u003E), along with time of death\u0026nbsp;\u003Cem\u003Et*\u003C\/em\u003E\u0026nbsp;and population-scale mortality\u0026nbsp;\u003Cem\u003Em\u003C\/em\u003E(\u003Cem\u003Et\u003C\/em\u003E)\u0026nbsp;across a cohort of infected animals, including a novel bioinformatic methodology for analysis. Finally, I link my conceptual questions to empirical data gathered with my developed platform. Using a 46 worm cohort, I show that that pathogen burden \u003Cem\u003Ep\u003C\/em\u003E(\u003Cem\u003Et\u003C\/em\u003E) is a weakly declining function of time since infection in the majority of individual worms, and across worms the estimated instantaneous risk of death \u003Cem\u003Em\u003C\/em\u003E(\u003Cem\u003Et\u003C\/em\u003E) accelerates in time. These results are not consistent with models where pathogen expansion is the cause of death, and indicate instead that initial high (and lethal) pathogen gut inocula are being partially cleared.\u0026nbsp;This work\u0026nbsp;offers a high throughput platform to link within-host pathogen dynamics to epidemiological parameters using a robust, genetically tractable host \/ pathogen\u0026nbsp;system.\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"The Dynamics of death: determining the relationship between within-host pathogen dynamics and host mortality"}],"uid":"27707","created_gmt":"2020-07-31 17:10:32","changed_gmt":"2020-07-31 17:10:32","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2020-08-11T14:00:00-04:00","event_time_end":"2020-08-11T16:00:00-04:00","event_time_end_last":"2020-08-11T16:00:00-04:00","gmt_time_start":"2020-08-11 18:00:00","gmt_time_end":"2020-08-11 20:00:00","gmt_time_end_last":"2020-08-11 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}