{"636806":{"#nid":"636806","#data":{"type":"event","title":"PhD Proposal by Veronica Montgomery ","body":[{"value":"\u003Cp\u003EVeronica Montgomery\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBME PhD Thesis Proposal Presentation\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDate: July 14\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETime: 2-4 pm\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELocation: Bluejeans (join info at end of email)\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ECommittee members: Mark Prausnitz (advisor), Mark Styczynski, Neha Garg, James Dahlman, Krish Roy\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETitle: Engineering the Skin Microbiome for Drug Delivery\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAbstract:\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETopical drug delivery is convenient for patients because the skin is a highly accessible tissue that allows simple self-application of therapies. However, topical drug delivery formulations are limited in their ability to deliver drugs for long periods of time, which limits their suitability for chronic conditions. The skin microbiome, which consists of many commensal species of bacteria that can colonize the skin for months to years, could be used to address these limitations if commensal bacteria were engineered to act as a long-term drug delivery platform for the skin. The objective of this proposal is to evaluate a bacteria-based drug delivery platform for topical therapy using\u0026nbsp;\u003Cem\u003EBacillus subtilis\u003C\/em\u003E, a genetically tractable organism that is found in the skin microbiome. The feasibility of using\u0026nbsp;\u003Cem\u003EBacillus subtilis\u003C\/em\u003E\u0026nbsp;as a skin drug delivery platform will be assessed using\u0026nbsp;\u003Cem\u003Ein vitro\u003C\/em\u003E\u0026nbsp;and\u0026nbsp;\u003Cem\u003Ein vivo\u003C\/em\u003E\u0026nbsp;skin models, with green fluorescent protein as a proof of concept. Finally, two potential applications of this platform will be explored by engineering\u0026nbsp;\u003Cem\u003EBacillus subtilis\u003C\/em\u003E\u0026nbsp;to overproduce the antifungal molecule iturin A and the mosquito repelling molecule 2-phenylethanol.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMeeting URL\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/bluejeans.com\/645365153?src=join_info\u0022\u003Ehttps:\/\/bluejeans.com\/645365153?src=join_info\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMeeting ID\u003C\/p\u003E\r\n\r\n\u003Cp\u003E645 365 153\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWant to dial in from a phone?\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDial one of the following numbers:\u003C\/p\u003E\r\n\r\n\u003Cp\u003E+1.408.419.1715 (United States(San Jose))\u003C\/p\u003E\r\n\r\n\u003Cp\u003E+1.408.915.6290 (United States(San Jose))\u003C\/p\u003E\r\n\r\n\u003Cp\u003E(see all numbers - \u003Ca href=\u0022https:\/\/www.bluejeans.com\/premium-numbers\u0022\u003Ehttps:\/\/www.bluejeans.com\/premium-numbers\u003C\/a\u003E)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEnter the meeting ID and passcode followed by #\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EConnecting from a room system?\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDial: bjn.vc or 199.48.152.152 and enter your meeting ID \u0026amp; passcode\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Engineering the Skin Microbiome for Drug Delivery "}],"uid":"27707","created_gmt":"2020-07-08 12:41:06","changed_gmt":"2020-07-08 12:41:06","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2020-07-14T15:00:00-04:00","event_time_end":"2020-07-14T17:00:00-04:00","event_time_end_last":"2020-07-14T17:00:00-04:00","gmt_time_start":"2020-07-14 19:00:00","gmt_time_end":"2020-07-14 21:00:00","gmt_time_end_last":"2020-07-14 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}