Calhoun and his research team have developed data-driven approaches to combine or “fuse” multimodal brain imaging and genomics data, such as structural and functional MRI and single nucleotide polymorphism data. They are using these approaches to extract biological fingerprints of healthy and disordered brains resulting from conditions such as schizophrenia and Alzheimer’s disease. These approaches are also being used to develop predictors of brain disorder, treatment response, and other measures with a goal of moving toward biology-based markers of illness. 

Calhoun is a Georgia Research Alliance Eminent Scholar and the founding director of the Center for Translational Research in Neuroimaging and Data Science (TReNDS) at Georgia State University. TReNDS is a tri-institutional effort among Georgia State, Georgia Tech, and Emory University. Effective July 1, Calhoun will also lead the Georgia State/Georgia Tech Center for Advanced Brain Imaging (CABI). He holds faculty appointments in Tech’s School of Electrical and Computer Engineering and the Wallace H. Coulter Department of Biomedical Engineering.