{"634940":{"#nid":"634940","#data":{"type":"news","title":"Dobromir Rahnev Awarded $2.2 Million by NIH to Study Architecture of Metacognition and a Promising Treatment for Neuropsychiatric Disorders: TMS-fMRI","body":[{"value":"\u003Cp\u003EAn assistant professor in the \u003Ca href=\u0022https:\/\/psychology.gatech.edu\/\u0022\u003ESchool of Psychology\u003C\/a\u003E has been awarded\u0026nbsp;$2.2 million in \u003Ca href=\u0022https:\/\/www.nih.gov\/\u0022\u003ENational Institutes of Health\u003C\/a\u003E (NIH) grants for two research proposals that could provide scientists more guidance for navigating the brain\u0026rsquo;s landscape.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/psychology.gatech.edu\/people\/faculty\/399\u0022\u003EDobromir Rahnev\u0026rsquo;s\u003C\/a\u003E NIH research will focus on the parts of the brain that are involved in decision making, and will also study how a promising treatment for neuropsychiatric disorders could be made more effective.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026ldquo;I am very excited to receive these grants as they will allow us to perform important research on metacognition and on brain processing more generally,\u0026rdquo; Rahnev says.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026ldquo;Uncovering the Architecture of Metacognition\u0026rdquo; will focus on the phenomenon of hierarchical noise architecture, and how it effects the ability to reflect on, and evaluate, one\u0026rsquo;s behavior. Problems with metacognition have been potentially linked to a number of psychiatric disorders, including schizophrenia, depression, and obsessive compulsive disorder (OCD). People who suffer brain lesions may have metacognition issues, and it may even be tied to substance abuse.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERahnev says learning more about hierarchical noise architecture will be important. \u0026ldquo;Consider decision making as a two-step process,\u0026rdquo; he says. \u0026ldquo;First, one makes a decision that can be about anything. Second, one needs to make a metacognitive judgment about how likely the original decision is to be correct. The central tenet of our proposal is that the metacognitive decision inherits the noise, biases, and inefficiencies of the first decision, and is additionally corrupted by what we call metacognitive noise. This noise can come from multiple sources, and this is part of what we plan to investigate.\u0026rdquo;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe second NIH research proposal, \u0026ldquo;Improving Behavior with TMS: A Concurrent TMS-fMRI Approach\u0026rdquo;, focuses on transcranial magnetic stimulation (TMS), which is a non-invasive procedure using magnetic fields to stimulate nerve cells in the brain. It has shown promise in treating major neuropsychological conditions such as Alzheimer\u0026rsquo;s disease, and it has been approved by the Food and Drug Administration for treatment of depression. But TMS\u0026rsquo; effects can vary from patient to patient.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBy combining TMS with functional magnetic resonance imaging (fMRI), \u0026ldquo;we hope that our research will help improve its effectiveness, but we won\u0026rsquo;t directly test patients,\u0026rdquo; Rahnev says. \u0026ldquo;Instead, our proposal is focused on understanding how TMS affects brain function, and whether its effects can be predicted by the pre-existing brain state. TMS is usually applied by itself, which makes this question difficult to address.\u0026rdquo;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHence the proposal to have TMS applied while a patient is inside an MRI scanner engaging in cognitive tasks. \u0026ldquo;This will allow us to determine what features of brain activity predict when TMS is helpful or detrimental to performance. Based on these insights, we hope to develop methods that could be used to improve the usefulness of TMS in both basic and clinical research though this will need to be done in a follow-up project.\u0026rdquo;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERahnev writes about his research combining TMS and fMRI on his website for his \u003Ca href=\u0022http:\/\/rahnevlab.gatech.edu\/\u0022\u003EComputational Cognitive Neuroscience\u003C\/a\u003E research group. \u0026ldquo;We use a variety of methods such as functional magnetic resonance imaging, transcranial magnetic stimulation, psychophysics, and computational modeling. We also strongly support open science and share the data and code for all our papers.\u0026rdquo;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":[{"value":"Rahnev will map the brain\u2019s landscape and study concurrent \u2018transcranial magnetic stimulation-functional magnetic resonance imaging\u2019 (TMS-fMRI), through two major NIH proposals "}],"field_summary":[{"value":"\u003Cp\u003EAn assistant professor in the School of Psychology will get more than $2 million in National Institutes of Health grants for two research proposals that focus on the brain\u0026#39;s decision-making abilities, and on a promising treatment for neuropsychiatric disorders.\u0026nbsp;\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"Rahnev will map the brain\u2019s landscape and study concurrent \u2018transcranial magnetic stimulation-functional magnetic resonance imaging\u2019 (TMS-fMRI), through two major NIH proposals "}],"uid":"34434","created_gmt":"2020-05-01 15:44:25","changed_gmt":"2020-05-01 16:17:51","author":"Renay San Miguel","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2020-05-01T00:00:00-04:00","iso_date":"2020-05-01T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"634941":{"id":"634941","type":"image","title":"School of Psychology Assistant Professor Dobromir Rahnev demonstrates the application of transcranial magnetic stimulation (TMS) in a Georgia Tech psychology research center with graduate student Ji-Won Jung. (Photo Georgia Tech\/Rob Felt)","body":null,"created":"1588348293","gmt_created":"2020-05-01 15:51:33","changed":"1588348293","gmt_changed":"2020-05-01 15:51:33","alt":"","file":{"fid":"241630","name":"Doby TMS test .png","image_path":"\/sites\/default\/files\/images\/Doby%20TMS%20test%20.png","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/Doby%20TMS%20test%20.png","mime":"image\/png","size":1238120,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Doby%20TMS%20test%20.png?itok=j2wYsQdl"}},"634942":{"id":"634942","type":"image","title":"Graphic representation of the human brain ","body":null,"created":"1588348460","gmt_created":"2020-05-01 15:54:20","changed":"1588348460","gmt_changed":"2020-05-01 15:54:20","alt":"","file":{"fid":"241631","name":"Brain neuroscience graphic.png","image_path":"\/sites\/default\/files\/images\/Brain%20neuroscience%20graphic.png","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/Brain%20neuroscience%20graphic.png","mime":"image\/png","size":685677,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Brain%20neuroscience%20graphic.png?itok=lP6s6Ecz"}}},"media_ids":["634941","634942"],"related_links":[{"url":"https:\/\/cos.gatech.edu\/news\/rahnev-receives-office-naval-research-young-investigator-award","title":"Rahnev Receives Office of Naval Research Young Investigator Award"},{"url":"https:\/\/rh.gatech.edu\/news\/606589\/i-saw-brain-mechanisms-create-confidence-about-things-seen","title":"I Saw That. Brain Mechanisms Create Confidence About Things Seen"},{"url":"https:\/\/www.news.gatech.edu\/2017\/06\/26\/bs-neuroscience-takes-georgia-tech","title":"B.S. in Neuroscience Takes Off at Georgia Tech"},{"url":"https:\/\/www.news.gatech.edu\/2016\/05\/09\/out-mind-out-sight","title":"Out of Mind, Out of Sight"}],"groups":[{"id":"1278","name":"College of Sciences"},{"id":"443951","name":"School of Psychology"}],"categories":[{"id":"138","name":"Biotechnology, Health, Bioengineering, Genetics"}],"keywords":[{"id":"4896","name":"College of Sciences"},{"id":"167710","name":"School of Psychology"},{"id":"170258","name":"Dobromir Rahnev"},{"id":"2270","name":"National Institutes of Health"},{"id":"178187","name":"metacognition"},{"id":"178127","name":"transcranial magnetic stimulation"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ERenay San Miguel\u003Cbr \/\u003E\r\nCommunications Officer\u003Cbr \/\u003E\r\nCollege of Sciences\u003Cbr \/\u003E\r\n404-894-5209\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","format":"limited_html"}],"email":["renay.san@cos.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}