{"634417":{"#nid":"634417","#data":{"type":"event","title":"PhD Defense by  Simone Douglas","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ESimone Douglas\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME PhD Thesis Defense\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate:\u003C\/strong\u003E\u0026nbsp;April 24\u003Csup\u003Eth\u003C\/sup\u003E, 2020\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime:\u003C\/strong\u003E\u0026nbsp;1:00PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBlueJeans Link:\u0026nbsp;\u003C\/strong\u003E\u0026nbsp;\u003Ca href=\u0022https:\/\/primetime.bluejeans.com\/a2m\/live-event\/tpbbpzcy\u0022 target=\u0022_blank\u0022\u003Ehttps:\/\/primetime.bluejeans.com\/a2m\/live-event\/tpbbpzcy\u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EManu O. Platt, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEdward Botchwey, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJohnna Temenoff, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERodney Averett, PhD (University of Georgia)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EClint Joiner, MD, PhD (Emory University \u0026amp; Children\u0026rsquo;s Healthcare of Atlanta)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERoger Kamm, PhD (Massachusetts Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u0026nbsp;Cathepsin-Mediated Fibrin(ogen)olysis in Engineered Microvascular Networks and Chronic Coagulation in Sickle Cell Disease\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ECysteine cathepsins are powerful proteases involved in tissue destructive disease progression, including angiogenesis and pathogenic vascular remodeling. However, some of their functions and mechanisms in biological processes remains unclear. For example, their potential role in polymerizing and degrading fibrin, an essential blood clotting protein and biomaterial scaffold for tissue repair, is not well characterized. The\u0026nbsp;\u003Cem\u003Ecentral hypothesis\u003C\/em\u003E\u0026nbsp;of this dissertation is that cysteine cathepsins have fibrin(ogen)olytic properties which can facilitate fibrin matrix remodeling. To identify the role of cathepsin-mediated fibrin(ogen)olysis we investigated, firstly, fibrin-based constructs as a biological mimicking test bed and secondly, sickle cell disease for a pathological condition. Our results show that fibrin is a novel substrate for human cysteine cathepsins, with unique properties to sustain activity over extended periods of time. This work contributes to our understanding of the role of cathepsin-mediated fibrin degradation\u0026nbsp;\u003Cem\u003Ein vitro\u0026nbsp;\u003C\/em\u003Eand how cathepsins remodel matrix of microvascular networks, as well as identifying cathepsin involvement in chronic coagulation activation in sickle cell anemia.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Cathepsin-Mediated Fibrin(ogen)olysis in Engineered Microvascular Networks and Chronic Coagulation in Sickle Cell Disease"}],"uid":"27707","created_gmt":"2020-04-15 19:33:00","changed_gmt":"2020-04-15 19:33:00","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2020-04-24T14:00:00-04:00","event_time_end":"2020-04-24T16:00:00-04:00","event_time_end_last":"2020-04-24T16:00:00-04:00","gmt_time_start":"2020-04-24 18:00:00","gmt_time_end":"2020-04-24 20:00:00","gmt_time_end_last":"2020-04-24 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}