{"634145":{"#nid":"634145","#data":{"type":"event","title":"PhD Defense by Bailey Hannon","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EBailey Hannon\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBioE PhD Defense Presentation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003E1:00 p.m., Monday, April 20, 2020\u003C\/em\u003E\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022https:\/\/bluejeans.com\/597317477\u0022\u003E\u003Cstrong\u003EBlueJeans\u003C\/strong\u003E\u003C\/a\u003E\u003Cstrong\u003E Meeting ID: 597317477 \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EC. Ross Ethier\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E, PhD, Co-Advisor (\u003C\/em\u003E\u003Cem\u003EWallace H. Coulter Department of \u003C\/em\u003E\u003Cem\u003EBiomedical Engineering, Georgia Institute of Technology and Emory University)\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EMachelle Pardue\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E, PhD, Co-Advisor (\u003C\/em\u003E\u003Cem\u003EWallace H. Coulter Department of Biomedical Engineering\u003C\/em\u003E\u003Cem\u003E, Georgia Institute of Technology and Emory University)\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EBrandon Dixon\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E, PhD (George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology)\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EMark Prausnitz\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E, PhD (Chemical and Biomolecular Engineering, Georgia Institute of Technology)\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EBrian Samuels\u003C\/em\u003E\u003C\/strong\u003E\u003Cem\u003E, MD, PhD (Department of Ophthalmology, University of Alabama, Birmingham)\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EStiffening the Posterior Rat Sclera to Provide Neuroprotection in Glaucoma\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGlaucoma is the leading cause of irreversible blindness in the world, expected to affect approximately 80 million people by the year 2020. This degenerative optic neuropathy is characterized by retinal ganglion cell (RGC) death, optic nerve damage, and progressive vision loss. While the exact etiology remains elusive, elevated intraocular pressure (IOP) is a known risk factor and lowering IOP remains the only effective treatment. Elevated IOP causes deformation and remodeling of the optic nerve head (ONH) tissues, which in turn is thought to promote localized neurodegeneration. Computational and \u003Cem\u003Eex vivo\u003C\/em\u003E studies have shown that scleral stiffness strongly influences deformation of the ONH, and that increasing the stiffness of the sclera surrounding the ONH (the peripapillary sclera) can significantly reduce these excessive strains. We \u003Cstrong\u003Ehypothesize\u003C\/strong\u003E that by crosslinking the collagenous peripapillary sclera, we will reduce mechanical deformation in the ONH, which will in turn mitigate glaucomatous vision loss.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETo investigate this hypothesis, we developed a safe and efficacious scleral stiffening treatment using the collagen crosslinking agent, genipin through \u003Cem\u003Eex vivo\u003C\/em\u003E and \u003Cem\u003Ein vivo\u003C\/em\u003E experiments in healthy rat eyes. We then evaluated our treatment\u0026rsquo;s efficacy to prevent glaucomatous damage in a microbead rat model of ocular hypertension. \u003Cstrong\u003EOur results indicate\u003C\/strong\u003E that scleral stiffening protects against retinal thinning but does not show protective effects on visual or retinal function, nor preservation of RGC axons. Overall, these results demonstrate the feasibility of using genipin for a scleral stiffening treatment. The absence of a strong protective effect of genipin-induced scleral stiffening on RGC function and structure may be due to limitations in the glaucomatous rat model, in that our model does not mirror the slow progression, nor the moderate IOP elevation characteristic of clinical glaucoma.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Stiffening the Posterior Rat Sclera to Provide Neuroprotection in Glaucoma"}],"uid":"27707","created_gmt":"2020-04-07 16:29:15","changed_gmt":"2020-04-07 16:29:15","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2020-04-20T14:00:00-04:00","event_time_end":"2020-04-20T16:00:00-04:00","event_time_end_last":"2020-04-20T16:00:00-04:00","gmt_time_start":"2020-04-20 18:00:00","gmt_time_end":"2020-04-20 20:00:00","gmt_time_end_last":"2020-04-20 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}