{"633738":{"#nid":"633738","#data":{"type":"event","title":"PhD Defense by Shaquia Idlett-Ali","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EShaquia Idlett-Ali\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME PhD Defense Presentation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate:\u0026nbsp;\u0026nbsp;\u003C\/strong\u003EMonday, March 23, 2020\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime:\u0026nbsp;\u003C\/strong\u003E3:00 PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBluejeans:\u0026nbsp;\u003C\/strong\u003E\u003Ca href=\u0022https:\/\/primetime.bluejeans.com\/a2m\/live-event\/jcdrpwfs\u0022 target=\u0022_blank\u0022\u003Ehttps:\/\/primetime.bluejeans.com\/a2m\/live-event\/jcdrpwfs\u003C\/a\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAdvisor: Shawn Hochman, Ph.D.(Emory SOM)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERobert Butera, Ph.D, P.E. (Georgia Tech-Emory)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELena Ting, Ph.D. (Georgia Tech-Emory)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESandra Garraway, Ph.D. (Emory SOM)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETimothy Cope, Ph.D (Georgia Tech)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u0026nbsp;Investigations of spontaneous pain and modulation with spinal cord stimulation\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EChronic pain is the leading cause of long-term disability.\u0026nbsp;Heterogeneity in etiology and manifestation of neuropathic pain\u0026nbsp;contribute to difficulties finding broadly effective pain management strategies. In cases\u0026nbsp;where pharmacological treatment has failed to provide relief, epidural spinal cord stimulation\u0026nbsp;(SCS) has emerged as an alternative intervention for intractable pain. This technology\u0026nbsp;has been in clinical use for over 50 years, yet efficacy rates have remained stagnant and\u0026nbsp;etiology-dependent. A barrier to improved efficacy is an absence of knowledge identifying\u0026nbsp;the mechanism by which SCS can selectively inhibit chronic, spontaneous pain.\u0026nbsp;The\u0026nbsp;gate control theory presents a theoretical framework of the therapy\u0026rsquo;s mechanism of action,\u0026nbsp;but the true mechanisms remain unclear.\u0026nbsp;This is further complicated by the absence of\u0026nbsp;spontaneous pain models and metrics for quantifying them.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe objective of this dissertation was to generate knowledge that leads to a better understanding\u0026nbsp;of both spontaneous neuropathic pain and SCS pain relief. To do this, I first identified\u0026nbsp;links between spontaneous sensory hyperexcitability and stimulus-independent\u0026nbsp;physio-behavioral indices of pain, using a contusion model of spinal cord injury.\u0026nbsp;Next, I used an\u0026nbsp;\u003Cem\u003Eex vivo\u003C\/em\u003E\u0026nbsp;adult mouse spinal cord preparation to assess\u0026nbsp;axonal recruitment with SCS. A computational model was utilized to inform parameter selection for examining clinically-analogous SCS with our model system.\u0026nbsp;Finally, I\u0026nbsp;tested the gate control theory by examining SCS modulation in an\u0026nbsp;\u003Cem\u003Eex vivo\u003C\/em\u003E\u0026nbsp;model of spontaneous\u0026nbsp;pain.\u0026nbsp;For these studies, I extended the spinal cord preparation to include intact\u0026nbsp;dorsal root ganglia from multiple lumbar segments and characterized spontaneous activity\u0026nbsp;in primary afferents and spinal nociceptive circuits. I then employed a threshold-based approach to examine SCS modulation of spontaneous nociceptive activity using traditional frequencies of SCS.\u0026nbsp;Results indicate\u0026nbsp;that antidromic afferent recruitment alone is not sufficient to replicate aspects of SCS modulation observed clinically.\u0026nbsp;Together, these findings provide greater insight into the identification\u0026nbsp;of spontaneous neuropathic pain and the underlying mechanisms leading to pain relief with\u0026nbsp;SCS.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Investigations of spontaneous pain and modulation with spinal cord stimulation"}],"uid":"27707","created_gmt":"2020-03-23 20:18:26","changed_gmt":"2020-03-23 20:18:26","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2020-03-23T17:14:00-04:00","event_time_end":"2020-03-23T17:14:00-04:00","event_time_end_last":"2020-03-23T17:14:00-04:00","gmt_time_start":"2020-03-23 21:14:00","gmt_time_end":"2020-03-23 21:14:00","gmt_time_end_last":"2020-03-23 21:14:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}