{"633274":{"#nid":"633274","#data":{"type":"event","title":"BioE PhD Proposal Presentation- Karen Martin","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAndr\u0026eacute;s Garc\u0026iacute;a,\u0026nbsp;Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEdward Botchwey, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ENick Willett, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELevi Wood, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEsma Yolcu, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBiomaterial-directed mesenchymal stem cell immunomodulation for enhanced bone repair outcomes\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe immunomodulatory and pro-regenerative functions of mesenchymal stem cells (MSC) make them an attractive cell source for use in regenerative medicine applications. However, clinical translation is hampered by poor control over MSC survival, localization, phenotype, and secretome upon transplantation \u003Cem\u003Ein vivo,\u003C\/em\u003E as well as an incomplete understanding of how therapeutically delivered MSC interact with the host immune system to promote positive wound healing outcomes. The objective of this project is to utilize hydrogel delivery vehicles to promote MSC survival and immunomodulation \u003Cem\u003Ein vivo \u003C\/em\u003Eand to evaluate the immune responses to these hydrogel-MSC therapies in a bone repair environment. This will be achieved through two specific aims: (1) Integrin-specific hydrogels will be evaluated for their ability to promote MSC persistence and immunomodulatory functions upon injection \u003Cem\u003Ein vivo\u003C\/em\u003E in immunocompetent mouse models. As there are several known species differences between human and murine immune cells and MSC, biomaterial-directed MSC secretome production and immune cell interactions will be evaluated in both a murine model using murine MSC and a humanized mouse model using human MSC, allowing for direct comparisons between species. (2) The impact of hydrogel-delivered MSC on bone healing and immune cell recruitment and phenotype over time will be evaluated in a murine segmental bone defect model. Using a combination of mass cytometry and single cell RNA-sequencing, key immune cell subpopulations that drive positive biomaterial-delivered MSC-dependent bone repair outcomes will be identified. The results of this proposal will yield critical insights into MSC-immune cell interactions \u003Cem\u003Ein vivo\u003C\/em\u003E and identify a means of modulating these interactions through the use of biomaterial-based MSC delivery vehicles.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation- \u0026quot;Biomaterial-directed mesenchymal stem cell immunomodulation for enhanced bone repair outcomes\u0026quot; -Karen Martin\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Biomaterial-directed mesenchymal stem cell immunomodulation for enhanced bone repair outcomes\u0022"}],"uid":"27917","created_gmt":"2020-03-04 15:52:45","changed_gmt":"2020-03-04 15:52:45","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2020-03-17T15:30:00-04:00","event_time_end":"2020-03-17T17:30:00-04:00","event_time_end_last":"2020-03-17T17:30:00-04:00","gmt_time_start":"2020-03-17 19:30:00","gmt_time_end":"2020-03-17 21:30:00","gmt_time_end_last":"2020-03-17 21:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\r\n\r\n\u003Cp\u003E404-385-6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}