{"632042":{"#nid":"632042","#data":{"type":"event","title":"Phd Proposal by Ursula Saelzler","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EName:\u003C\/strong\u003E \u003Cstrong\u003EUrsula Saelzler\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDissertation Proposal Meeting\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u003Cstrong\u003EDate:\u003C\/strong\u003E February 4, 2020\u003Cbr \/\u003E\r\n\u003Cstrong\u003ETime:\u003C\/strong\u003E\u0026nbsp;10:00 am\u003Cbr \/\u003E\r\n\u003Cstrong\u003ELocation:\u0026nbsp;\u003C\/strong\u003EJ.S. Coon Building, Room 150\u003Cbr \/\u003E\r\n\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003Cbr \/\u003E\r\nScott Moffat, Ph.D. (Georgia Tech)\u003Cbr \/\u003E\r\n\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cstrong\u003EThesis Committee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMark Wheeler, Ph.D. (Georgia Tech)\u003Cbr \/\u003E\r\nThackery Brown, Ph.D. (Georgia Tech)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPaul Verhaeghen, Ph.D. (Georgia Tech)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMatt Panizzon, Ph.D. (UC San Diego)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003Cbr \/\u003E\r\n\u003Cstrong\u003ETitle: A longitudinal investigation of cortisol as a driver of amyloid deposition in older adults\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAmyloid \u0026beta; (A\u0026szlig;) deposition has been considered a hallmark of Alzheimer\u0026rsquo;s disease (AD) since its initial description at the start of the 20\u003Csup\u003Eth\u003C\/sup\u003E century. Nearly 100 years later, the advent of the positron-emission tomography (PET) radiotracer Pittsburgh Compound-B (PIB) enabled the in vivo measurement of amyloid deposition. Research using PIB has demonstrated that A\u0026szlig; accumulation may begin nearly two decades before clinical diagnosis of AD and that greater deposition increases risk for the development of sporadic AD in older adults. The utility of PIB measured during this preclinical phase to predict AD onset coupled with the failure of anti-amyloid treatments targeted at individuals diagnosed with AD or mild cognitive impairment (MCI) has spurred research aimed at determining factors which may influence amyloid deposition, particularly during the preclinical phase. In recent years, the steroid hormone cortisol has been proposed as a stimulant of A\u0026szlig; accumulation on the basis of in vitro and rodent studies. The proposed study would represent the first longitudinal investigation of the relationship between cortisol and A\u0026szlig; accumulation in humans, using the changes to changes extension of the bivariate latent difference score model to test whether changes in cortisol precede changes in A\u0026szlig; deposition in vivo.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"A longitudinal investigation of cortisol as a driver of amyloid deposition in older adults"}],"uid":"27707","created_gmt":"2020-02-03 18:37:19","changed_gmt":"2020-02-03 18:37:19","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2020-02-04T10:00:00-05:00","event_time_end":"2020-02-04T12:00:00-05:00","event_time_end_last":"2020-02-04T12:00:00-05:00","gmt_time_start":"2020-02-04 15:00:00","gmt_time_end":"2020-02-04 17:00:00","gmt_time_end_last":"2020-02-04 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}