{"630225":{"#nid":"630225","#data":{"type":"event","title":"PhD Defense by Chance Meers","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDoctor of Philosophy in Biology\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ein the\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EChance Meers\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ewill defend his dissertation\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca name=\u0022_Hlk27556444\u0022\u003E\u003C\/a\u003E\u003Ca name=\u0022_Hlk25757947\u0022\u003E\u003C\/a\u003E\u003Cstrong\u003EMolecular Mechanisms of RNA-mediated DNA Repair and Modification\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWednesday, January 8th, 2019\u003C\/p\u003E\r\n\r\n\u003Cp\u003E3:00 PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003EKrone Engineered Biosystems Building\u003C\/p\u003E\r\n\r\n\u003Cp\u003EChildren\u0026#39;s Healthcare of Atlanta Seminar Room\u0026nbsp;(1005)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Francesca Storici\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Kirill Lobachev\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Frank Rosenzweig\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Loren Williams\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Chemistry and Biochemistry\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Anita Corbett\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Biology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEmory University\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca name=\u0022_Hlk27556525\u0022\u003EGenomic stability is essential in maintaining the accurate inheritance of genetic material from mother to daughter cell. However, endogenous and exogenous stresses are continuously attacking and damaging genetic information. In responses, cells developed mechanisms to prevent and correct these damages. DNA can be damaged in a variety of different ways, with DNA double-stranded breaks being one of the most dangerous lesions. We recently showed that RNA can be used as a template for repair in budding yeast. Here, we investigate the molecular mechanisms by which RNA can template the repair of DNA damage. We determine the role of endogenous retrotransposons and characterize molecular components that are required for repair by reverse transcribed transcript-RNA. To better understand the role of RNA in directly templating DNA repair, we eliminated components required for retrotransposon-mediated repair events to find that RNA can directly template double-strand break repair. We show that this process is strongly reliant on translesion DNA polymerase \u0026zeta; (Zeta). Remarkably, we uncover a role of RNA directly modifying genomic DNA in the absence of induced DNA damage, revealing a novel role of translesion DNA synthesis. \u003C\/a\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Molecular Mechanisms of RNA-mediated DNA Repair and Modification "}],"uid":"27707","created_gmt":"2019-12-19 14:41:44","changed_gmt":"2019-12-19 14:41:44","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2020-01-08T15:00:00-05:00","event_time_end":"2020-01-08T17:00:00-05:00","event_time_end_last":"2020-01-08T17:00:00-05:00","gmt_time_start":"2020-01-08 20:00:00","gmt_time_end":"2020-01-08 22:00:00","gmt_time_end_last":"2020-01-08 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}