{"629388":{"#nid":"629388","#data":{"type":"event","title":"BioE PhD Defense Presentation- Tel Rouse","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u0026nbsp;\u003C\/strong\u003EHang Lu, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPatrick McGrath, Ph.D.\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMark Styczynski, Ph.D.\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERobert Butera, Ph.D.\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EYun Zhang, Ph.D.\u0026nbsp;(Harvard University)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EMICROFLUIDIC-BASED TOOLS AND METHODS FOR COMPLEX CHEMOSENSORY AND CHEMOTAXIS STUDIES IN \u003Cem\u003EC. ELEGANS\u003C\/em\u003E\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThere is a great interest in studying behavior and the underlying biological basis for behaviors in small model organisms. Some properties of \u003Cem\u003EC. elegans\u003C\/em\u003E that greatly facilitate genetic investigations are its small size, relatively simplistic \u0026lsquo;brain\u0026rsquo;, complex repertoire of behaviors, and ease of isogenic population studies. In order to take full advantage of these characteristics, it is desirable to have methods for analyzing behaviors of large populations of animals in well controlled environments. One set of behaviors extensively used to investigate numerous phenomena in neurobiology within \u003Cem\u003EC. elegans\u003C\/em\u003E deals with the navigation of chemical environments (chemotaxis). Studies based on \u003Cem\u003EC. elegans\u003C\/em\u003E chemotaxis are used in investigating chemosensation, innate preferences, learning, memory, and more. We have improved upon previous microfluidic and computer-vision technologies to advance \u003Cem\u003EC. elegans\u003C\/em\u003E chemosensation and chemotaxis studies to answer more sophisticated biological questions. One developed method is a microfluidic device capable of monitoring animal neuronal activity in vivo while delivering multiple chemical stimuli to animals at sub-second speeds and in any desired order. This method facilitates investigations as to how complex environmental stimulus changes are encoded within a simple, well-characterized nervous system at relevant behavioral timescales. The second developed method is a microfluidic platform and accompanying software capable of tracking a population of \u003Cem\u003EC. elegans\u003C\/em\u003E freely navigating well-controlled, spatial chemical environments over long timescales. Via this method, complete behavioral and stimulus experience history profiles can be generated for each animal within a population. This enables correlations to be made between acute chemotaxis behaviors and animal stimulus histories which provides unique opportunities for novel insights into \u003Cem\u003EC. elegans\u003C\/em\u003E neurobiology studies.\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Defense Presentation-\u0026nbsp; \u0026quot;MICROFLUIDIC-BASED TOOLS AND METHODS FOR COMPLEX CHEMOSENSORY AND CHEMOTAXIS STUDIES IN C. ELEGANS\u0026quot; -Tel Rouse\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022MICROFLUIDIC-BASED TOOLS AND METHODS FOR COMPLEX CHEMOSENSORY AND CHEMOTAXIS STUDIES IN C. ELEGANS\u0022"}],"uid":"27917","created_gmt":"2019-11-26 15:58:48","changed_gmt":"2019-11-26 15:58:48","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-12-10T10:00:00-05:00","event_time_end":"2019-12-10T12:00:00-05:00","event_time_end_last":"2019-12-10T12:00:00-05:00","gmt_time_start":"2019-12-10 15:00:00","gmt_time_end":"2019-12-10 17:00:00","gmt_time_end_last":"2019-12-10 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\r\n\r\n\u003Cp\u003E404-385-6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}