{"628937":{"#nid":"628937","#data":{"type":"event","title":"Micro-Physiological Systems Series: Bioengineered Human iPSC Tissue Model for Gaining Mechanistic and Therapeutic Insights into CPVT","body":[{"value":"\u003Ch3\u003EMicro-Physiological Systems Series: Bioengineered Human iPSC Tissue Model for Gaining Mechanistic and Therapeutic Insights into CPVT\u003C\/h3\u003E\r\n\r\n\u003Ch5\u003ESpeaker: Sung Jin Park, Ph.D. - Assistant Professor, Coulter Department of Biomedical Engineering; Georgia Institute of Technology \u0026amp; Emory University School of Medicine\u003C\/h5\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E The cellular phenotypes caused by inherited arrhythmia mutations have been studied using human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs). However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of these mutations on tissue-level properties of human myocardium has not been reported. In this talk, I will present an in vitro hiPSC-CM-based platform to study the tissue-level properties of engineered human myocardium. I will illustrate how this hiPSCCM- based platform can be used to investigate pathogenic mechanisms in the deadly, exercise-triggered inherited arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT). In addition, I will show how we combined this novel platform with genome editing and identified new therapeutic target for CPVT.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELunch Provided at 1pm\u003Cbr \/\u003E\r\nRSVP link: https:\/\/forms.gle\/5VV1PzeduPaUBEKg8\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cbr \/\u003E\r\n\u003Cstrong\u003EBlueJeans: https:\/\/bluejeans.com\/870397059\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"In this talk, I will present an in vitro hiPSC-CM-based platform to study the tissue-level properties of engineered human myocardium."}],"uid":"27863","created_gmt":"2019-11-13 15:36:17","changed_gmt":"2019-11-13 15:37:18","author":"Christa Ernst","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-11-20T13:00:00-05:00","event_time_end":"2019-11-20T14:00:00-05:00","event_time_end_last":"2019-11-20T14:00:00-05:00","gmt_time_start":"2019-11-20 18:00:00","gmt_time_end":"2019-11-20 19:00:00","gmt_time_end_last":"2019-11-20 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":["free_food"],"groups":[{"id":"213791","name":"3D Systems Packaging Research Center"},{"id":"198081","name":"Georgia Electronic Design Center (GEDC)"},{"id":"197261","name":"Institute for Electronics and Nanotechnology"},{"id":"1271","name":"NanoTECH"},{"id":"213771","name":"The Center for MEMS and Microsystems Technologies"}],"categories":[],"keywords":[{"id":"12427","name":"microfluidics"},{"id":"9540","name":"Bioengineering and Bioscience"},{"id":"4891","name":"Tissue Engineering"},{"id":"183063","name":"stem cell derivitives"},{"id":"107","name":"Nanotechnology"},{"id":"12701","name":"Institute for Electronics and Nanotechnology"},{"id":"108031","name":"College of Engineering; Coulter Department of Biomedical Engineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EYong Yu: tyu44@gatech.edu\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}