{"627779":{"#nid":"627779","#data":{"type":"event","title":"Mechanics and Epigenetics Double Seminar Double Seminar ","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0026ldquo;The Mechanics of Fracture and Adhesion of Polymer Coatings\u0026rdquo;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EMichael Thouless, Ph.D.\u003Cbr \/\u003E\r\nProfessor, Mechanical Engineering\u003Cbr \/\u003E\r\nProfessor, Materials Science and Engineering\u003Cbr \/\u003E\r\nArthur F. Thurnau Professor, Mechanical Engineering\u003Cbr \/\u003E\r\nJanine Johnson Weins Professor\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe first concept that will be explored in this talk is the time-dependent nature of cracking in polymeric coatings, with a particular interest in the coatings for automotive polymeric glazing. Experiments suggest that crack velocities in these particular systems, while sensitive to visco-elastic properties, are controlled by kinetic processes.\u003Cbr \/\u003E\r\nThe second topic will address the adhesion of ice to polymeric coatings. In particular, the work illustrates the dual role that both interfacial strength and interfacial toughness play in determining the conditions for delamination. Experimental studies show that the force required to delaminate a layer of ice from a polymeric coating depends on the scale of the problem.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026ldquo;Collecting Long-range Genetic and Epigenetic Information at the Single-molecule Level\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EYifan Liu, Ph.D.\u003Cbr \/\u003E\r\nResearch Assistant Professor, Epigenetics and Chromatin Biology\u003Cbr \/\u003E\r\nDepartment of Pathology\u003Cbr \/\u003E\r\nMichigan Medicine\u003Cbr \/\u003E\r\nUniversity of Michigan\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERecent developments in sequencing and optical mapping technologies open up new possibilities to collect long-range genetic and epigenetic information at the single-molecule level. \u0026nbsp;Three platforms from PacBio, Oxford Nanopore Technologies, and Bionano Genomics will be surveyed, exploring their potentials and limitations. \u0026nbsp;In particular, PacBio sequencing has been successfully used for mapping in eukaryotic cells the distribution of N6-methyladenine (6mA), a DNA base modification. \u0026nbsp;The sequencing results support 6mA as a transcription-associated epigenetic mark, and suggest a molecular mechanism for its maintenance after DNA replication.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EPizza will be served!\u003C\/em\u003E\u003C\/strong\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Professors Michael Thouless, Ph.D.  and Yifan Liu, Ph.D. - University of Michigan presenting. "}],"uid":"27349","created_gmt":"2019-10-18 15:20:58","changed_gmt":"2019-10-18 15:24:44","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-10-21T15:15:00-04:00","event_time_end":"2019-10-21T16:15:00-04:00","event_time_end_last":"2019-10-21T16:15:00-04:00","gmt_time_start":"2019-10-21 19:15:00","gmt_time_end":"2019-10-21 20:15:00","gmt_time_end_last":"2019-10-21 20:15:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"https:\/\/www.pathology.med.umich.edu\/faculty\/yifan","title":"Liu profile"},{"url":"https:\/\/me.engin.umich.edu\/people\/faculty\/michael-thouless","title":"Thouless profile"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:takayama@gatech.edu\u0022\u003EShuichi Takayama\u003C\/a\u003E\u0026nbsp;- faculty host\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}