{"625447":{"#nid":"625447","#data":{"type":"event","title":"PhD Proposal by Abigail Paulson","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAbigail Paulson\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME PhD Proposal Presentation\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate: \u003C\/strong\u003EMonday, September 16th, 2019\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime: \u003C\/strong\u003E1:00 pm\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation: \u003C\/strong\u003EHSRB E160\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAnnabelle Singer, PhD (Advisor)\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJames Lah, MD, PhD\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERobert Liu, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJoseph Manns, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGarrett Stanley, PhD\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u0026nbsp;\u003C\/strong\u003EBringing gamma back: the\u0026nbsp;effects of non-invasive gamma\u0026nbsp;stimulation on neural activity in a mouse model\u0026nbsp;of Alzheimer\u0026rsquo;s\u0026nbsp;disease\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAlzheimer\u0026rsquo;s disease\u0026nbsp;(AD) is a devastating neurodegenerative disorder that is characterized by\u0026nbsp;the\u0026nbsp;accumulation of toxic proteins, aberrant neural activity, and deficits in\u0026nbsp;spatial learning and\u0026nbsp;memory. The hippocampus, an area of the brain crucial for\u0026nbsp;spatial learning and memory, is\u0026nbsp;affected early in the course of AD.\u0026nbsp;Previously, we\u0026nbsp;discovered that acute exposure to 40 Hz\u0026nbsp;auditory and light flicker stimulation\u0026nbsp;drives gamma frequency neural activity in the\u0026nbsp;hippocampus. Furthermore,\u0026nbsp;extending gamma stimulation exposure from acute presentations\u0026nbsp;to multiple days\u0026nbsp;of stimulation periods reduces amyloid beta levels, recruits microglia to\u0026nbsp;engulf\u0026nbsp;amyloid beta, and improves performance in spatial memory tasks in a\u0026nbsp;mouse model of AD.\u0026nbsp;However, it is unknown how prolonged manipulation of\u0026nbsp;hippocampal activity impacts deficits in\u0026nbsp;neural activity crucial for learning\u0026nbsp;and memory.\u0026nbsp;Thus, the\u0026nbsp;goal\u0026nbsp;of this proposal\u0026nbsp;is to study the\u0026nbsp;functional effects of gamma frequency\u0026nbsp;sensory stimulation on deficits in neural connections\u0026nbsp;and neural codes\u0026nbsp;essential for learning and memory in the hippocampus of a mouse model of\u0026nbsp;AD.\u0026nbsp;Aim\u0026nbsp;1\u0026nbsp;will establish how prolonged gamma stimulation affects deficient\u0026nbsp;inhibition of\u0026nbsp;excitatory pyramidal cells in the hippocampus.\u0026nbsp;Aim 2\u0026nbsp;will\u0026nbsp;examine the effects of prolonged\u0026nbsp;gamma stimulation on deficits in patterns of\u0026nbsp;hippocampal activity that are important for\u0026nbsp;learning and memory. To achieve\u0026nbsp;these aims, local field potentials and spiking activity will be\u0026nbsp;recorded from\u0026nbsp;many single neurons in head-fixed mice as they navigate through a virtual\u0026nbsp;reality (VR) environment. This\u0026nbsp;innovative\u0026nbsp;approach\u0026nbsp;will allow neural activity to be recorded\u0026nbsp;from awake, behaving\u0026nbsp;mice, the primary animal model of disease, with the high temporal\u0026nbsp;resolution\u0026nbsp;and large number of cells needed to study precise neural activity in the\u0026nbsp;hippocampus.\u0026nbsp;The proposed work has the\u0026nbsp;potential to result in a non-invasive method to\u0026nbsp;rescue neural activity\u0026nbsp;deficits, carrying promising translational applications to Alzheimer\u0026rsquo;s\u0026nbsp;disease,\u0026nbsp;as well as other neurological diseases with altered oscillatory neural\u0026nbsp;activity.\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Bringing gamma back: the effects of non-invasive gamma stimulation on neural activity in a mouse model of Alzheimer\u2019s disease"}],"uid":"27707","created_gmt":"2019-09-03 13:28:02","changed_gmt":"2019-09-03 13:28:02","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-09-16T14:00:00-04:00","event_time_end":"2019-09-16T16:00:00-04:00","event_time_end_last":"2019-09-16T16:00:00-04:00","gmt_time_start":"2019-09-16 18:00:00","gmt_time_end":"2019-09-16 20:00:00","gmt_time_end_last":"2019-09-16 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}