{"622750":{"#nid":"622750","#data":{"type":"event","title":"PhD Proposal by Aaron Blanchard","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAaron Blanchard\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME PhD Proposal Presentation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate:\u003C\/strong\u003E July 2nd, 2019\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime: \u003C\/strong\u003E9:00-11:00am\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation:\u003C\/strong\u003E Atwood 360 (Emory)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EKhalid Salaita, PhD (Emory University, Chemistry) (Advisor)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETodd Sulchek, PhD (Georgia Institute of Technology, School of Mechanical Engineering)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EYonggang Ke, PhD (Emory University, Biomedical Engineering)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEric Weeks, PhD (Emory University, Physics)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EKeir Neuman, PhD (National Institute of Health)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E Highly polyvalent DNA motors for molecular detection and nanorobotics\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMolecular motors such as kinesin and myosin are ubiquitous in eukaryotes and power countless processes including muscle contraction, embryogenesis, and wound closure. The ability to engineer synthetic molecular motors that mirror the functions of biological motors will be an important step in the development of active and responsive materials of the future. DNA-based walking motors, which use DNA \u0026ldquo;feet\u0026rdquo; to translocate across molecular tracks, are the most promising synthetic analogues of molecular motors because they recapitulate the processive stepping behavior of biological motors. However, conventional DNA walkers translocate at speeds and forces that are orders of magnitude lower than biological motors. We have demonstrated progress towards addressing this limitation by developing highly polyvalent DNA motors (HPDMs), which simultaneously use thousands of DNA feet to reach speeds as high as 10 micrometers per minute and generate forces as high as 150 piconewtons, comparable to biological motors.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWe achieve high polyvalency by attaching DNA feet to microspheres five-micrometers in diameter. While we propose to leverage this relatively large size to perform molecular detection using a cellphone microscope (Aim 1), the current size prevents applications at the nanoscale. We predict that we can reduce HPDM volume 2,000-fold without substantially reducing speed or force by conjugating DNA feet to rod-shaped, rather than spherical, particles (Aim 2). We also aim to control HPDM motion to perform massively parallel nanolithography (Aim 3). This work will help pave the way for next-generation active and responsive materials and, as such, will be accompanied by detailed observational studies and computational and theoretical modeling (Aim 4) that will help to elucidate the fundamental scaling properties of HPDMs and similar motors.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Highly polyvalent DNA motors for molecular detection and nanorobotics"}],"uid":"27707","created_gmt":"2019-06-25 12:35:34","changed_gmt":"2019-06-25 12:35:34","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-07-02T10:00:00-04:00","event_time_end":"2019-07-02T12:00:00-04:00","event_time_end_last":"2019-07-02T12:00:00-04:00","gmt_time_start":"2019-07-02 14:00:00","gmt_time_end":"2019-07-02 16:00:00","gmt_time_end_last":"2019-07-02 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}