{"622036":{"#nid":"622036","#data":{"type":"event","title":"Phd Proposal by Lena Gamboa","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ELena Gamboa\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME PhD Proposal Presentation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate:\u003C\/strong\u003E June 10th, 2019\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime: \u003C\/strong\u003E2:00-3:00pm\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation:\u003C\/strong\u003E IBB Suddath Room 1128\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGabe Kwong, PhD (Georgia Institute of Technology, Biomedical Engineering) (Advisor)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAndr\u0026eacute;s Garc\u0026iacute;a, PhD (Georgia Institute of Technology, School of Mechanical Engineering)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJames Dahlman, PhD (Georgia Institute of Technology, Biomedical Engineering)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ECostas Arvanitis, PhD (Georgia Institute of Technology, School of Mechanical Engineering)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHaydn Kissick, PhD (Emory University School of Medicine)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E Remote control of antitumor immunity against intracranial tumors\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ECytotoxic T lymphocytes (CTL) have tremendous curative potential as cell-based therapies for cancer and have proven effective across a range of tumor types, yet intracranial malignancies, such as glioblastomas (GBM), remain a significant challenge. Despite significant advances in the treatment of hematological cancers with T cells bearing chimeric antigen receptors (CARs), brain tumors escape engineered T cell recognition by employing a number of antigen escape strategies and by harboring immunosuppressive microenvironments that impede T cell function. These include antigen mutation or antigen loss and inhibition through immune checkpoint pathways PD-1 and CTLA-4. Moreover, biologics designed to enhance T cell activity (e.g., IL-2) or block inhibitory signals (e.g., \u0026alpha;PD-1) affect both antitumor and endogenous T cell populations, resulting in widespread systemic toxicities that include off-target cell killing. Thus, methods that can enable spatially-defined control of T cell effector function and promote recognition of synthetic antigens by CAR T cells could convert immunologically \u0026ldquo;cold\u0026rdquo; tumors to \u0026ldquo;hot\u0026rdquo; and make aggressive malignancies, such as GBM, more vulnerable to effective antitumor T cell responses.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EInspired by the precision by which thermal cues can be delivered noninvasively by various approaches such as high-intensity focused ultrasound (FUS), we propose to engineer bioswitches (Aim 1) that allow for thermal control of T cell effector function in vivo (Aim 2). We will test our thermal control system in the setting of adoptive T cell transfer in preclinical models of GBM and breast cancer brain metastasis. Additionally, we propose to deliver synthetic antigens to render immune evasive GBM tumors vulnerable to CAR T cell recognition (Aim 3). This framework may improve the efficacy of engineered T cell responses against refractory malignant brain tumors.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Remote control of antitumor immunity against intracranial tumors"}],"uid":"27707","created_gmt":"2019-05-28 19:20:26","changed_gmt":"2019-05-28 19:20:26","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-06-10T15:00:00-04:00","event_time_end":"2019-06-10T16:00:00-04:00","event_time_end_last":"2019-06-10T16:00:00-04:00","gmt_time_start":"2019-06-10 19:00:00","gmt_time_end":"2019-06-10 20:00:00","gmt_time_end_last":"2019-06-10 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}