{"621505":{"#nid":"621505","#data":{"type":"event","title":"PhD Proposal by Joshua Palacios","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EJoshua Palacios\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME PhD Proposal Presentation\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate:\u0026nbsp;\u003C\/strong\u003EMay 21\u003Csup\u003Est\u003C\/sup\u003E, 2019\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime:\u0026nbsp;\u003C\/strong\u003E3:00PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation:\u0026nbsp;\u003C\/strong\u003ERoom L1175, Ford ES\u0026amp;T building\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMark Prausnitz, PhD (Georgia Institute of Technology, School of Chemical and Biomolecular Engineering) (Advisor)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJulie Champion, PhD (Georgia Institute of Technology, School of Chemical and Biomolecular Engineering)\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWilbur Lam, MD, PhD (Georgia Institute of Technology, School of Biomedical Engineering)\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETodd Sulchek, PhD (Georgia Institute of Technology, School of Biomedical Engineering)\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAndrew Neish, MD (Emory University, School of Medicine)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle: Ballistic Delivery to the Gastrointestinal Tract\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u0026nbsp;\u003C\/strong\u003EBiologic therapies are often the gold standard for managing a variety of chronic diseases and are usually administered through repeated injections, sometimes throughout a patient\u0026rsquo;s lifetime. These injections, which must be given by healthcare professionals or trained patients, are painful and can increase patient non-compliance, cost of therapy, scar tissue formation at sites of repeated administration, and risk of spreading blood borne diseases. Oral delivery is preferred, but there are physiological barriers within the gastrointestinal tract (GIT) that typically reduce bioavailability of biologics to less than 2%. These barriers include: fluctuating pH levels, secretion of enzymes, a thick mucus barrier (MB), and an epithelial cell layer (ECL). Researchers have shown that nanoparticle (NP) encapsulation can protect biologics from pH denaturation, enzymatic degradation, and facilitate transport into the ECL, but the mucus covering the ECL remains a significant barrier. Generally, oral delivery of NPs relies on diffusion of NPs through mucus. This MB is several hundred microns thick and employs numerous entrapping strategies which dramatically inhibit NP diffusion. Some NPs can be designed to slowly circumvent entrapment, but mucus is constantly being secreted and renewed, causing NP excretion out of the GIT before they can reach the ECL.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETherefore,\u0026nbsp;we propose using a ballistic delivery approach to overcome mucus barriers within the GIT. We hypothesize that an \u0026ldquo;active\u0026rdquo; transport of NPs across the MB (propelling NPs through mucus) would lead to greater oral bioavailability of biologics\/NPs compared to \u0026ldquo;passive\u0026rdquo; transport (diffusion). As such, this proposal aims to engineer an oral delivery system that can propel biologics\/NPs through mucosal barriers in the GIT. Preliminary\u0026nbsp;\u003Cem\u003Eex vivo\u0026nbsp;\u003C\/em\u003Eporcine intestinal experiments have shown delivery across the MB for various sized polymeric NPs, from a range of velocities, using an external particle shooter device. We have also developed preliminary prototypes of oral delivery systems that can release NPs with high velocity in a safe and controlled\/directed manner under simulated\u0026nbsp;\u003Cem\u003Ein vivo\u0026nbsp;\u003C\/em\u003Econditions. Therefore, in this proposal we aim to (1) determine the effect of NP parameters and shooting conditions on penetration through the MB in porcine intestinal tissue\u0026nbsp;\u003Cem\u003Eex vivo\u0026nbsp;\u003C\/em\u003Eand rat\/rabbit intestinal tissue\u0026nbsp;\u003Cem\u003Ein vivo,\u0026nbsp;\u003C\/em\u003E(2) develop a delivery system suitable for oral administration that can ballistically deliver payloads at controlled optimal parameters quantified in previous animal studies, and (3) demonstrate that ballistic delivery using our novel oral delivery system leads to higher bioavailability in a rabbit\/porcine animal model\u0026nbsp;\u003Cem\u003Ein vivo\u003C\/em\u003E. This proposed research will help provide an oral alternative delivery for biologics that is safe, painless, and eliminates the need for repeated biologic injection therapies.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Ballistic Delivery to the Gastrointestinal Tract"}],"uid":"27707","created_gmt":"2019-05-08 17:05:08","changed_gmt":"2019-05-08 17:05:08","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-05-21T16:00:00-04:00","event_time_end":"2019-05-21T18:00:00-04:00","event_time_end_last":"2019-05-21T18:00:00-04:00","gmt_time_start":"2019-05-21 20:00:00","gmt_time_end":"2019-05-21 22:00:00","gmt_time_end_last":"2019-05-21 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}