{"621404":{"#nid":"621404","#data":{"type":"event","title":"PhD Defense by Aline L.Y. Nachlas","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAline\u0026nbsp;L.Y. Nachlas\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBME\u0026nbsp;Ph.D.\u0026nbsp;Defense\u0026nbsp;Presentation\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate:\u003C\/strong\u003E\u0026nbsp;Monday, May 20\u003Csup\u003Eth\u003C\/sup\u003E, 2019\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime:\u003C\/strong\u003E\u0026nbsp;3:00 PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation:\u003C\/strong\u003E\u0026nbsp;HSRB E160\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMichael E. Davis,\u0026nbsp;PhD\u0026nbsp;(Advisor)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EK. Jane Grande-Allen, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWilbur Lam, MD,\u0026nbsp;PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWei Sun,\u0026nbsp;PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJohnna S. Temenoff,\u0026nbsp;PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EChunhui Xu,\u0026nbsp;PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle: \u003C\/strong\u003EEngineering an aortic valve with cellular and mechanical functionality\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract: \u003C\/strong\u003EHeart valve disease is an increasing clinical burden associated with high morbidity and mortality. Current, valve replacements have a number of risks, such as thrombogenicity and calcification. For pediatric patients, a significant issue is the lack of small implants capable of growing, resulting in several surgical interventions for valve refitting. Patient-specific, tissue engineered heart valves (TEHVs) have the potential to address these issues through their self-repairing and remodeling capacity. The overall objective of this thesis was to develop a TEHV that functions under physiological aortic valve conditions and has the potential to repair and remodel over time. The central hypothesis is a TEHV can be created by mimicking the structural components of the valve leaflet layers using 3D bioprinting and incorporating valvular interstitial cell (VIC)-like cells to actively regenerate and remodel. First, we generated a potential suitable cell source of human iPSC-derived mesenchymal stem cells (iMSCs) that mature into VIC-like cells. Next, we used 3D printing and a combination of poly-\u0026epsilon;-caprolactone (PCL) and gelatin methacrylate - polyethylene (glycol) diacrylate (GelMA\/PEGDA) hydrogel to create a cell-laden multilayered leaflet that recapitulates the layers of the valve leaflet. Lastly, the PCL component of the valve leaflet was mounted onto a valve stent and feasibility studies were conducted using a left-ventricle flow simulator to evaluate the hemodynamic performance of the PCL-TEHV under aortic valve conditions. We demonstrated a cell source can be derived from autologous iPSCs, generated a multilayered leaflet scaffold using a combination of natural and synthetic biomaterials, and verified the feasibility of the leaflet under aortic flow conditions. These promising findings are the first steps to a pre-clinical TEHV with the ability to regenerate and remodel with the patient.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Engineering an aortic valve with cellular and mechanical functionality"}],"uid":"27707","created_gmt":"2019-05-06 18:26:59","changed_gmt":"2019-05-06 18:26:59","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-05-20T16:00:00-04:00","event_time_end":"2019-05-20T18:00:00-04:00","event_time_end_last":"2019-05-20T18:00:00-04:00","gmt_time_start":"2019-05-20 20:00:00","gmt_time_end":"2019-05-20 22:00:00","gmt_time_end_last":"2019-05-20 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}