Our understanding of how genomes are organized inside the interphase nucleus, and of the molecular factors involved, is rapidly improving. In this talk, first, I will review some of the recent research that has led to this current understanding. However, I will then present a number of results, including measurements of chromatin dynamics in living cells, that challenge aspects of this picture. I will then develop and explore a modified hypothesis for the mechanisms underlying genome organization. Finally, I will compare the consequences of our modified model of chromatin organization to genome-wide experimental data.
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