{"619101":{"#nid":"619101","#data":{"type":"event","title":"PhD Defense by Mengnan Zhang","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDoctor of Philosophy in Bioinformatics\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ein the\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EMengnan Zhang\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ewill defend her thesis:\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAnalysis of the role of miRNAs in ovarian cancer metastasis\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETuesday, March 26\u003Csup\u003Eth\u003C\/sup\u003E, 2019\u003C\/p\u003E\r\n\r\n\u003Cp\u003E1:00 PM Eastern Time\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEngineered Biosystems Building, Children\u0026#39;s Healthcare of Atlanta Seminar Room (EBB 1005)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. John F. McDonald\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Jung H. Choi\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. I. King Jordan\u003Cbr \/\u003E\r\nSchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Fredrik O. Vannberg\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Ronghu Wu\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Chemistry \u0026amp; Biochemistry\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ECancer mortality is primarily due to metastasis. Metastasis is a complex multi-step process involving, on the molecular level, regulatory control of two key development pathways: epithelial-to-mesenchymal transition (EMT) and it reciprocal, mesenchymal-to-epithelial transition (MET). MiRNAs are small regulatory RNA molecules that play key roles in the regulation of EMT\/MET. In this thesis, I examine the role of miRNAs in regulating EMT\/MET in ovarian cancer. In the first study, I show that sequentially divergent miRNAs converge to regulate the EMT\/MET process through both direct and indirect regulatory changes. In the second study, I explore the impact of genetic difference between different cancer cell lines on the function of miRNAs to regulate the EMT\/MET process. In the third study, I evaluate the importance of post-transcriptional\/translational changes in the metastasis of a stage III ovarian cancer patient and the role played by miRNAs in regulating the process.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Analysis of the role of miRNAs in ovarian cancer metastasis"}],"uid":"27707","created_gmt":"2019-03-11 18:01:20","changed_gmt":"2019-03-11 18:01:20","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-03-26T14:00:00-04:00","event_time_end":"2019-03-26T16:00:00-04:00","event_time_end_last":"2019-03-26T16:00:00-04:00","gmt_time_start":"2019-03-26 18:00:00","gmt_time_end":"2019-03-26 20:00:00","gmt_time_end_last":"2019-03-26 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}