{"618848":{"#nid":"618848","#data":{"type":"event","title":"PhD Defense by Wen Xu","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDoctor of Philosophy in Biology\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ein the\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EWen Xu\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ewill defend her dissertation\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ENematodes Adapt Using Yin-yang Isoforms of a NURF Subunit\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETuesday,\u0026nbsp;March 19th,\u0026nbsp;2019\u003C\/p\u003E\r\n\r\n\u003Cp\u003E9:00\u0026nbsp;AM\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEngineered Biosystems Building (EEB)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EChildren\u0026#39;s Healthcare of Atlanta Seminar Room\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr.\u0026nbsp;Patrick T. McGrath\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee members:\u003C\/strong\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr.\u0026nbsp;Jeffrey T. Streelman\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Greg Gibson\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of\u0026nbsp;Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr.\u0026nbsp;Annalise B. Paaby\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of\u0026nbsp;Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr.\u0026nbsp;David Katz\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Cell Biology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEmory University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cbr \/\u003E\r\n\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ESummary\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EConvergent or parallel evolution is the repeated evolution of the same genotype in independent populations in response to similar environmental changes. A growing number of examples of parallel evolution are accumulating in the literature (e.g. \u003Cem\u003Ecis\u003C\/em\u003E-regulatory changes in the \u003Cem\u003Eshavenbaby\u003C\/em\u003E developmental regulator in \u003Cem\u003EDrosophila\u003C\/em\u003E species result in dorsal cuticle hair loss (Sucena \u0026amp; Stern 2000), repeated selection on the \u003Cem\u003EEda\u003C\/em\u003E TNF ligand causes stickleback low-plated phenotype (Colosimo et al. 2005), and deletion of chemoreceptor genes contribute to the insensitivity to a specific pheromone in \u003Cem\u003ECaenorhabditis\u003C\/em\u003E species (McGrath et al. 2011)). In this dissertation, I will discuss my studies of how \u003Cem\u003ECaenorhabditis elegans\u003C\/em\u003E strains adapt to laboratory environments. I will describe how two \u003Cem\u003EC. elegans\u003C\/em\u003E strains N2 and LSJ2, who share a common ancestor but have evolved independently in laboratory conditions have increased fitness in their respective environment. I will show that part of adaptation in the LSJ2 strain is caused by a 60 bp deletion in \u003Cem\u003Enurf-1\u003C\/em\u003E gene, a subunit of nucleosome remodeling factor NURF. Next, I will describe my finding about that adaptation of the N2 lineage is partially caused by a SNV in the 2\u003Csup\u003End\u003C\/sup\u003E intron of \u003Cem\u003Enurf-1\u003C\/em\u003E. This work suggests that \u003Cem\u003Enurf-1\u003C\/em\u003E is a common target of evolution in response to laboratory growth. Finally, I will describe my work to understand why \u003Cem\u003Enurf-1\u003C\/em\u003E might be targeted, which I propose is due to the antagonistic function (here I refer as Yin-yang) of two major \u003Cem\u003Enurf-1 \u003C\/em\u003Eisoforms on the sexual fate during gametogenesis. My doctoral thesis study advance our understanding of how nucleosome remodeling factor may work and that isoform-level study of complex genes is feasible and necessary.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Nematodes Adapt Using Yin-yang Isoforms of a NURF Subunit"}],"uid":"27707","created_gmt":"2019-03-05 20:35:19","changed_gmt":"2019-03-05 20:35:19","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-03-19T10:00:00-04:00","event_time_end":"2019-03-19T12:00:00-04:00","event_time_end_last":"2019-03-19T12:00:00-04:00","gmt_time_start":"2019-03-19 14:00:00","gmt_time_end":"2019-03-19 16:00:00","gmt_time_end_last":"2019-03-19 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}