{"618512":{"#nid":"618512","#data":{"type":"event","title":"PhD Proposal by Ian Miller","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EIan Miller\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EPhD Proposal Presentation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate:\u003C\/strong\u003E\u0026nbsp;March 12, 2019\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime:\u003C\/strong\u003E\u0026nbsp;10:00 am\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation:\u003C\/strong\u003E\u0026nbsp;EBB Room 3029\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Gabriel Kwong, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWallace H. Coulter Department of Biomedical Engineering\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology and Emory University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members\u003C\/strong\u003E:\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Koichi Araki\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDepartment of Microbiology and Immunology\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEmory University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Erik Dreaden\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWallace H. Coulter Department of Biomedical Engineering\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology and Emory University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Krishnendu Roy\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWallace H. Coulter Department of Biomedical Engineering\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology and Emory University\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Susan Thomas\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorge W. Woodruff School of Mechanical Engineering\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u0026nbsp;\u0026quot;Remote Control of Adoptive T cell Therapies\u0026quot;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERecent advances in engineered T cell therapies are providing physicians with a rapidly expanding repertoire of cell-based treatments to fight cancers that are otherwise refractory to conventional treatments. For example, strategies harnessing T cells engineered with chimeric antigen receptors (CARs) have resulted in dramatic disease regression, and in some patients, completely curative responses. Yet despite such striking progress, our ability to precisely control the cytotoxic activity of adoptively transferred T cells in vivo remains limited \u0026ndash; especially within solid tumors. In contrast to hematological malignancies, solid tumors have the uncanny ability to evade the immune system by creating an immunosuppressive microenvironment that inhibits effector cells\u0026rsquo; ability to kill tumor cells. Furthermore, CARs target antigens expressed by both diseased and healthy tissues and the inability to tune CAR T cell activity has resulted in deleterious, off-tumor effects ranging from B cell aplasia to Cytokine Release Syndrome (CRS) and fatal off-target cytotoxicity. Ideally the next generation of engineered T cell therapies would include the capacity to be remotely controlled by external cues, such as light or heat, to enable localized control of immune responses including cytokine signaling, maintenance and proliferation of effector populations, and anti-tumor cytotoxicity. Achieving this degree of precision will increase the safety and potency of engineered T cell therapies for cancer. Inspired by thermal medicine, I will explore a framework for remote control of T cell therapies by heat. I propose engineering thermal gene switches to allow heat-triggered expression of potent immunostimulatory cytokines and expression of tumor-specific CARs; the therapeutic efficacy of this strategy will be evaluated in preclinical cancer models of adoptive cell therapies. I envision that the framework established by this proposal will provide clinicians new methods to treat unresponsive tumors and advance the field of precision medicine.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Remote Control of Adoptive T cell Therapies"}],"uid":"27707","created_gmt":"2019-02-27 13:54:44","changed_gmt":"2019-02-27 13:54:44","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-03-12T11:00:00-04:00","event_time_end":"2019-03-12T13:00:00-04:00","event_time_end_last":"2019-03-12T13:00:00-04:00","gmt_time_start":"2019-03-12 15:00:00","gmt_time_end":"2019-03-12 17:00:00","gmt_time_end_last":"2019-03-12 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}