Nanoparticle engineered at Georgia Tech may replace biopsy needles in detecting transplant organ rejection

Nanoparticle engineered at Georgia Tech may replace biopsy needles in detecting transplant organ rejection

A T cell, here in purple, makes contact with a transplant organ cell, here in reddish brown. The T cell secretes the enzyme granzyme B, here in gray, which attacks the organ cell. But granzyme B also severs fluorescent signal molecules, in green, from the rejection detecting nanoparticle, in light pink. The signal molecules make their way into the urine, where they give off a fluorescent cue. Georgia Tech / EllaMaru Studio (work for hire, all rights GT, free for distribution).

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Categories
Research, Biotechnology, Health, Bioengineering, Genetics, Chemistry and Chemical Engineering, Engineering, Life Sciences and Biology, Nanotechnology and Nanoscience
Keywords
Rejection, transplant, Transplant Failure, transplant complications, Transplant Biology, Organ Rejection, Transplant Rejection, nanoparticle, bionanotechnology, fluorescence, fluorescence detectors, Fluorescent Labeling, Fluorescent Molecules, Biopsy With Needle, biopsy-free diagnosis, Biopsies, Needle Biopsy, Coulter, granzyme B, T cell, early detection, Kidney Transplant, dextran, PEG, polyethylene glycol, Reporter, Infrared imaging, Immunosuppresion, Immunosuppresive, Immunosuppressant, immunosuppressant drugs, immunosuppressant medications, Immunosuppressants, Immunosuppressive
Status
  • Created By: Ben Brumfield
  • Workflow Status: Published
  • Created On: Feb 19, 2019 - 2:55pm
  • Last Updated: Feb 19, 2019 - 2:55pm