{"617404":{"#nid":"617404","#data":{"type":"event","title":"PhD Proposal by Nicholas Beskid","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ENicholas M. Beskid\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBioE PhD Proposal Presentation\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EFebruary 19, 2019 3pm.\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EU.A. Whitaker Building \u0026ndash; Room 3115\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJulie Babensee, PhD (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEdward Botchwey, PhD (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAndr\u0026eacute;s Garc\u0026iacute;a, PhD (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESusan Thomas, PhD (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJacob Kohlmeier, PhD (Emory University)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETolerized Dendritic Cells Delivered via PEG-4MAL Hydrogels for Amelioration of Multiple Sclerosis\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMultiple Sclerosis (MS) is an autoimmune disease that causes neurodegeneration and destruction of myelin in the CNS, resulting in physical and cognitive impairments. Currently there is no cure for MS and present treatment strategies can only slow disease progression and come with a myriad of complicated side effects. The purpose of this project is to (1) elucidate structure-function relationships between PEG-4MAL scaffolds and encapsulated dendritic cells (DCs), (2) incorporate adhesive and immunological cues to promote sustained function of tolerogenic DCs post-injection, and (3) evaluate the efficacy of hydrogel-delivered tolerogenic DCs to ameliorate autoimmune disease in a murine model of MS. Work outlined herein will uncover previously uncharacterized relationships between mechanical and adhesive properties of matrices on DC tolerogenicity for informed design of biomaterial delivery strategies. Proposed work will also provide a proof-of-concept treatment strategy for antigen-specific, DC-mediated treatment of MS. Immunological studies are expected to illustrate underlying mechanisms of amelioration and provide insight for further development of treatment strategies against autoimmunity.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Tolerized Dendritic Cells Delivered via PEG-4MAL Hydrogels for Amelioration of Multiple Sclerosis"}],"uid":"27707","created_gmt":"2019-02-06 15:17:53","changed_gmt":"2019-02-06 15:17:53","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-02-19T15:00:00-05:00","event_time_end":"2019-02-19T17:00:00-05:00","event_time_end_last":"2019-02-19T17:00:00-05:00","gmt_time_start":"2019-02-19 20:00:00","gmt_time_end":"2019-02-19 22:00:00","gmt_time_end_last":"2019-02-19 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}