{"616032":{"#nid":"616032","#data":{"type":"event","title":"PhD Proposal by Mark Conolly","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EPhD Proposal Presentation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate:\u003C\/strong\u003E\u0026nbsp;January 11, 2019\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime:\u003C\/strong\u003E 9:00\u0026nbsp;-\u0026nbsp;11:00\u0026nbsp;AM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEmory University Main Campus\u003C\/p\u003E\r\n\r\n\u003Cp\u003EWoodruff Memorial Research Building\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERoom 5101\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;Robert E. Gross, Neurosurgery, Biomedical Engineering, Georgia Tech\/Emory (Advisor)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAnnaelle Devergnas, Neurology, Emory University\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESvjetlana Miocinovic, Neurology, Biomedical Engineering, Georgia Tech\/Emory\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBabak Mahmoudi, Biomedical Informatics, Biomedical Engineering, Georgia Tech\/Emory\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EChris Rozell, Biomedical Engineering, Georgia Tech\/Emory\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle: \u003C\/strong\u003EA framework for optimizing neural modulation based on electrophysiological biomarkers\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u0026nbsp;Neural modulation is a fundamental tool for understanding and treating neurological and psychiatric diseases including Parkinson\u0026rsquo;s and epilepsy. Like most neurological tools, accurately measuring the effect of an intervention is time-consuming and imprecise. However, neural modulation poses an additional problem where stimulation parameters have many degrees of freedom including amplitude, location\/contact, frequency, etc. Black-box optimization techniques have the potential to automate the process of tuning stimulation parameters, efficiently search higher dimensional parameter spaces, and identify more effective parameter combinations. The objective of this proposal is to characterize the behavior different optimization algorithms for tuning stimulation parameters, and demonstrate closed-loop optimization \u003Cem\u003Ein vivo\u003C\/em\u003E. First, this project\u0026nbsp;establishes a framework for prototyping and designing optimization algorithms\u0026nbsp;\u003Cem\u003Ein silico\u003C\/em\u003E\u0026nbsp;based on previously collected data. The platform is developed in the context of modulating of hippocampal gamma (33-50Hz) power through optogenetic stimulation of the medial septum. Next,\u0026nbsp;the optimization system is implemented\u0026nbsp;\u003Cem\u003Ein vivo\u003C\/em\u003E\u0026nbsp;in real-time to directly learn the medial septum optogenetic stimulation parameters that maximize hippocampal gamma power in real-time\u003Cem\u003E.\u003C\/em\u003E\u0026nbsp;Finally, the\u0026nbsp;closed-loop optimization framework\u0026nbsp;is extended to\u0026nbsp;characterize functional differences in the septohippocampal circuit in normal and epileptic rats, and for optimizing DBS therapy for patients with Parkinson\u0026rsquo;s disease.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"A framework for optimizing neural modulation based on electrophysiological biomarkers "}],"uid":"27707","created_gmt":"2019-01-07 20:49:53","changed_gmt":"2019-01-07 20:53:38","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-01-11T09:00:00-05:00","event_time_end":"2019-01-11T11:00:00-05:00","event_time_end_last":"2019-01-11T11:00:00-05:00","gmt_time_start":"2019-01-11 14:00:00","gmt_time_end":"2019-01-11 16:00:00","gmt_time_end_last":"2019-01-11 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}