{"615054":{"#nid":"615054","#data":{"type":"event","title":"BioE PhD Proposal Presentation- Laura Weinstock","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELevi Wood, Ph.D. (Georgia Institute of Technology - ME)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMelissa Kemp, Ph.D. (Georgia Institute of Technology - BME)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAlicia Lyle, Ph.D. (Emory University\u0026nbsp;- Cardiology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EManu Platt, Ph.D. (Georgia Institute of Technology - BME)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESrikant Rangaraju,\u0026nbsp;Ph.D. (Emory University\u0026nbsp;-\u0026nbsp;Neurology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EKrishnendu Roy,\u0026nbsp;Ph.D. (Georgia Institute of Technology -\u0026nbsp;BME)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EFeedback Control of Macrophages and Microglia to Regulate Neuroinflammatory Dynamics\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EChronic neuroinflammation, including activation of macrophages and microglia, is a central component and likely driver of numerous neurodegenerative diseases, such as Alzheimer\u0026rsquo;s disease. There remains a critical unmet need to actively regulate glial activity in such diseases. \u003Cem\u003EI hypothesize that 1) macrophages and microglia may be actively regulated to achieve desired temporal profiles of inflammatory response and 2) modulating the temporal progression of inflammatory processes using active control strategies will improve pathophysiologic conditions in disease environments.\u003C\/em\u003E Specifically, I will regulate temporal macrophage and microglial polarization, which I will demonstrate is a controllable element of the larger immune response, to reduce gliosis, synaptic density and neuronal loss. My preliminary data in macrophages show that it is possible to define polarization response functions to exogenous stimulation, e.g., LPS, which can be quantitatively modeled using low order black-box models. This novel exogenous control methodology for regulating macrophage and microglial function will use a combination of data driven modeling and system dynamics and control theory. The black-box model enables reliable parameter estimation for predicting dynamic responses to future inputs I used the identified model as part of an open-loop control framework to tailor input sequences to obtain desired temporal trajectories of polarization. Moving forward, I will use a similar modeling framework applied to shift microglial phenotype between homeostatic, pro-inflammatory, and disease associated microglial states, recently defined by transcriptome-wide analysis. During this thesis, I will implement a closed-loop framework to regulate macrophage and microglial response \u003Cem\u003Ein vitro\u003C\/em\u003E. Moreover, I will develop a data-driven modeling framework to define and control temporal responses \u003Cem\u003Ein vivo\u003C\/em\u003E. Given the importance of dynamic pro- and anti-inflammatory activity in the AD brain, the control methodology presented here will have numerous applications for treating chronic neuroinflammatory diseases.\u003Ca id=\u0022LPlnk839532\u0022 name=\u0022_Toc531599408\u0022\u003E\u003C\/a\u003E\u003Ca id=\u0022LPlnk981688\u0022 name=\u0022_Toc531117197\u0022\u003E\u003C\/a\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation-\u0026nbsp;\u0026quot;FEEDBACK CONTROL OF MACROPHAGES AND MICROGLIA TO REGULATE NEUROINFLAMMATORY DYNAMICS\u0026quot; -\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELaura Weinstock\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022FEEDBACK CONTROL OF MACROPHAGES AND MICROGLIA TO REGULATE NEUROINFLAMMATORY DYNAMICS\u0022"}],"uid":"27917","created_gmt":"2018-12-06 14:06:27","changed_gmt":"2018-12-06 14:06:27","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2018-12-19T14:00:00-05:00","event_time_end":"2018-12-19T16:00:00-05:00","event_time_end_last":"2018-12-19T16:00:00-05:00","gmt_time_start":"2018-12-19 19:00:00","gmt_time_end":"2018-12-19 21:00:00","gmt_time_end_last":"2018-12-19 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"10377","name":"Career\/Professional development"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\r\n\r\n\u003Cp\u003E404-385-6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}