{"614803":{"#nid":"614803","#data":{"type":"event","title":"Spatial Architecture, Collective Antibiotic Resistance, and Evolution in Microbial Communities","body":[{"value":"\u003Ch3\u003ESchool of Physics Soft Condensed Matter \u0026amp; Physics of Living Systems Seminar: Prof. Kevin Wood, University of Michigan\u003C\/h3\u003E\r\n\r\n\u003Cp\u003EAntibiotic resistance is among the most urgent threats to public health. In this talk, I will discuss our group\u0026rsquo;s ongoing efforts to understand how\u0026nbsp;\u003Cem\u003EE. faecalis\u003C\/em\u003E, an opportunistic bacterial pathogen, responds to antibiotics across multiple length and time scales. First, I\u0026rsquo;ll describe recent experiments using customized, computer controlled bioreactors to demonstrate that growth inhibition depends strongly on population density for many commonly used antibiotics, potentially leading to bistable treatment outcomes in a pharmacological model of antibiotic treatment.\u003C\/p\u003E\r\n\r\n\u003Cp\u003EIn the limit of high population densities, subinhibitory antibiotic concentrations can promote formation of biofilms--an effect that reflects a trade-off between antibiotic efficacy and the beneficial effects of cell lysis--while higher doses can shape the single-cell architecture of drug resistant communities. Finally, I\u0026rsquo;ll overview ongoing work combining laboratory evolution with mathematical modeling aimed at slowing resistance evolution using temporal drug sequences designed to maximize collateral drug sensitivity over different time scales.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"School of Physics - Soft Condensed \u0026 Physics of Living Systems Seminar - Prof. Kevin Wood - University of Michigan"}],"uid":"30957","created_gmt":"2018-11-29 22:25:22","changed_gmt":"2018-12-19 21:38:01","author":"Shaun Ashley","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-01-15T15:00:00-05:00","event_time_end":"2019-01-15T16:00:00-05:00","event_time_end_last":"2019-01-15T16:00:00-05:00","gmt_time_start":"2019-01-15 20:00:00","gmt_time_end":"2019-01-15 21:00:00","gmt_time_end_last":"2019-01-15 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"614804":{"id":"614804","type":"image","title":"Prof. Kevin Wood","body":null,"created":"1543530392","gmt_created":"2018-11-29 22:26:32","changed":"1543530419","gmt_changed":"2018-11-29 22:26:59","alt":"","file":{"fid":"234082","name":"WoodKevin11.29.2018.jpg","image_path":"\/sites\/default\/files\/images\/WoodKevin11.29.2018.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/WoodKevin11.29.2018.jpg","mime":"image\/jpeg","size":42897,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/WoodKevin11.29.2018.jpg?itok=m3XTLQYg"}}},"media_ids":["614804"],"groups":[],"categories":[],"keywords":[{"id":"960","name":"physics"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003Eshaun.ashley@physics.gatech.edu\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}