{"614423":{"#nid":"614423","#data":{"type":"event","title":"PhD Proposal by Aaron Rosado","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAaron Rosado\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME PhD Proposal Presenation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate: \u003C\/strong\u003EDecember 3\u003Csup\u003Erd\u003C\/sup\u003E, 2018\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime: \u003C\/strong\u003E1:00pm\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation:\u003C\/strong\u003E McIntire Room\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAdvisor: \u003C\/strong\u003ECheng Zhu\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EArash Grakoui (Emory)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESusan Thomas (BME)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMichael Davis (BME)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMichelle Krogsgaard (NYU)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle: \u003C\/strong\u003EImpairment of Mechanosensing and Lateral Crosstalk Among Immune Receptors in Tumor Infiltrating Lymphocytes\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract\/Summary:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe tumor microenvironment\u0026rsquo;s (TME) unique immune characteristics play a major role in shaping tumor immune responses.\u0026nbsp; Immune cells infiltrating into the tumor microenvironment encounter unique microenvironmental cues potentially resulting in anti-tumor immune response suppression.\u0026nbsp; Immune checkpoint blockade (ICB) attempts to suppress inhibitory immune checkpoint receptors in ways that enhance anti-tumor immunity.\u0026nbsp; Although ICB clearly enhances cytotoxic potential in infiltrating cytotoxic T cells, many questions remain about immune checkpoint receptors function within the TME.\u0026nbsp; We propose that the TME impairs infiltrating cytotoxic T cell CD8, CD28, CTLA-4, and TCR complex mechanosensing and lateral crosstalk (LC).\u0026nbsp; We will investigate TME immune synapse receptor mechanosensing and LC impairment in infiltrating cytotoxic T cells with bond quality and quantity measurements.\u0026nbsp; We will employ biomechanical switching instrument techniques towards controlling LC spatially and temporally.\u0026nbsp; We will demonstrate immune synapse receptor mechanosensing and LC impairment functionally impairs T cell function and can be modulated with small molecule inhibitors.\u0026nbsp; We believe investigations into mechanosensing and LC impairment will provide invaluable immune checkpoint signaling insights and motivate cancer immunotherapy improvements.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Impairment of Mechanosensing and Lateral Crosstalk Among Immune Receptors in Tumor Infiltrating Lymphocytes"}],"uid":"27707","created_gmt":"2018-11-19 19:30:15","changed_gmt":"2018-11-19 19:30:15","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2018-12-03T13:00:00-05:00","event_time_end":"2018-12-03T15:00:00-05:00","event_time_end_last":"2018-12-03T15:00:00-05:00","gmt_time_start":"2018-12-03 18:00:00","gmt_time_end":"2018-12-03 20:00:00","gmt_time_end_last":"2018-12-03 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}