{"614225":{"#nid":"614225","#data":{"type":"event","title":"PhD Proposal by Matthew Cribb","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EMatthew Cribb\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBioE Ph.D. Proposal Presentation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETuesday, November 27\u003Csup\u003Eth\u003C\/sup\u003E, 2018 | 2:00 pm\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EEBB Room 4029\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJ. Brandon Dixon, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EKrishnendu Roy, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERudolph Gleason, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EFredrik Vannberg, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMark Nicolls, M.D. (Stanford University School of Medicine)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThe role of leukotriene B\u003Csub\u003E4\u003C\/sub\u003E in driving lymphatic failure in lymphedema\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELymphedema is a devastating disease that predominantly affects breast cancer patients post-surgery, leading to swelling at the extremities and tissue fibrosis. There are currently no pharmacological treatments available for lymphedema. However, LTB\u003Csub\u003E4\u003C\/sub\u003E, a metabolite of arachidonic acid, has been implicated in the development of lymphedema and identified as a possible drug target. The objective of this study is to determine if LTB\u003Csub\u003E4\u003C\/sub\u003E drives lymphatic collecting vessel failure. The hypothesis is that LTB\u003Csub\u003E4\u003C\/sub\u003E inhibits lymphatic collecting vessel contraction at high concentrations occurring post-injury, leading to lymphatic failure. We predict that this functional effect of LTB\u003Csub\u003E4\u003C\/sub\u003E occurs through two mechanisms; LTB\u003Csub\u003E4\u003C\/sub\u003E directly acts on lymphatic collecting vessels to inhibit pumping and LTB\u003Csub\u003E4\u003C\/sub\u003E drives macrophage recruitment to the site of injury. First, we will test LTB\u003Csub\u003E4\u003C\/sub\u003E\u0026rsquo;s direct effect on lymphatic collecting vessel contractility. Next, an LTB\u003Csub\u003E4\u003C\/sub\u003E antagonist will be used to treat mice induced with lymphedema to study how LTB\u003Csub\u003E4\u003C\/sub\u003E affects collecting vessel function during disease progression. A genetic macrophage depletion mouse model will be used to examine if there is a macrophage-mediated effect of LTB\u003Csub\u003E4\u003C\/sub\u003E on collecting vessel pump function during lymphedema development. The results of this study will help identify multiple mechanisms by which LTB\u003Csub\u003E4\u003C\/sub\u003E drives lymphatic collecting vessel pump failure.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"The role of leukotriene B4 in driving lymphatic failure in lymphedema"}],"uid":"27707","created_gmt":"2018-11-14 13:48:33","changed_gmt":"2018-11-14 13:48:33","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2018-11-27T14:00:00-05:00","event_time_end":"2018-11-27T16:00:00-05:00","event_time_end_last":"2018-11-27T16:00:00-05:00","gmt_time_start":"2018-11-27 19:00:00","gmt_time_end":"2018-11-27 21:00:00","gmt_time_end_last":"2018-11-27 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}