{"614186":{"#nid":"614186","#data":{"type":"event","title":"BioE PhD Proposal Presentation- Matthew Cribb","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJ. Brandon Dixon, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EKrishnendu Roy, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003ERudolph Gleason, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EFredrik Vannberg, Ph.D. (Georgia Institute of Technology)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMark Nicolls, M.D. (Stanford University School of Medicine)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThe role of leukotriene B\u003Csub\u003E4\u003C\/sub\u003E in driving lymphatic failure in lymphedema\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELymphedema is a devastating disease that predominantly affects breast cancer patients post-surgery, leading to swelling at the extremities and tissue fibrosis. There are currently no pharmacological treatments available for lymphedema. However, LTB\u003Csub\u003E4\u003C\/sub\u003E, a metabolite of arachidonic acid, has been implicated in the development of lymphedema and identified as a possible drug target. The objective of this study is to determine if LTB\u003Csub\u003E4\u003C\/sub\u003E drives lymphatic collecting vessel failure. The hypothesis is that LTB\u003Csub\u003E4\u003C\/sub\u003E inhibits lymphatic collecting vessel contraction at high concentrations occurring post-injury, leading to lymphatic failure. We predict that this functional effect of LTB\u003Csub\u003E4\u003C\/sub\u003E occurs through two mechanisms; LTB\u003Csub\u003E4\u003C\/sub\u003E directly acts on lymphatic collecting vessels to inhibit pumping and LTB\u003Csub\u003E4\u003C\/sub\u003E drives macrophage recruitment to the site of injury. First, we will test LTB\u003Csub\u003E4\u003C\/sub\u003E\u0026rsquo;s direct effect on lymphatic collecting vessel contractility. Next, an LTB\u003Csub\u003E4\u003C\/sub\u003E antagonist will be used to treat mice induced with lymphedema to study how LTB\u003Csub\u003E4\u003C\/sub\u003E affects collecting vessel function during disease progression. A genetic macrophage depletion mouse model will be used to examine if there is a macrophage-mediated effect of LTB\u003Csub\u003E4\u003C\/sub\u003E on collecting vessel pump function during lymphedema development. The results of this study will help identify multiple mechanisms by which LTB\u003Csub\u003E4\u003C\/sub\u003E drives lymphatic collecting vessel pump failure.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioE PhD Proposal Presentation-\u0026nbsp;\u0026quot;The role of leukotriene B4 in driving lymphatic failure in lymphedema\u0026quot;- Matthew Cribb\u003C\/p\u003E\r\n","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022The role of leukotriene B4 in driving lymphatic failure in lymphedema\u0022"}],"uid":"27917","created_gmt":"2018-11-13 14:42:26","changed_gmt":"2018-11-13 14:42:26","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2018-11-27T14:00:00-05:00","event_time_end":"2018-11-27T16:00:00-05:00","event_time_end_last":"2018-11-27T16:00:00-05:00","gmt_time_start":"2018-11-27 19:00:00","gmt_time_end":"2018-11-27 21:00:00","gmt_time_end_last":"2018-11-27 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"172056","name":"go-BioE"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1789","name":"Conference\/Symposium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\r\n\r\n\u003Cp\u003E404-385-6655\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}