{"613818":{"#nid":"613818","#data":{"type":"event","title":"Breakfast Club Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0026quot;RNA Profiling: Extracting Structural Signals from Noisy Distributions\u0026quot;\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nChristine Heitsch, Ph.D.\u003Cbr \/\u003E\r\nProfessor, School of Mathematics\u003Cbr \/\u003E\r\nGeorgia Tech\u003C\/strong\u003E\u003Cbr \/\u003E\r\n\u003Cbr \/\u003E\r\nAccurate RNA structural prediction remains challenging, despite its increasing biomedical importance. \u0026nbsp;Sampling secondary structures from the Gibbs distribution yields a strong signal of high probability base pairs. \u0026nbsp;However, identifying higher order substructures requires further analysis. \u0026nbsp;Profiling (Rogers \u0026amp; Heitsch, NAR, 2014) is a novel method which identifies the most probable combinations of base pairs across the Boltzmann ensemble. \u0026nbsp;This combinatorial approach is straightforward, stable, and clearly separates structural signal from thermodynamic noise. \u0026nbsp;Moreover, it can be extended to predict consensus stems for an RNA family with high accuracy via unsupervised clustering of unaligned homologous sequences.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"\u0022RNA Profiling: Extracting Structural Signals from Noisy Distributions\u0022 - Christine Heitsch, Ph.D. - Georgia Tech"}],"uid":"27195","created_gmt":"2018-11-05 12:31:53","changed_gmt":"2018-11-05 12:31:53","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-02-12T08:30:00-05:00","event_time_end":"2019-02-12T09:30:00-05:00","event_time_end_last":"2019-02-12T09:30:00-05:00","gmt_time_start":"2019-02-12 13:30:00","gmt_time_end":"2019-02-12 14:30:00","gmt_time_end_last":"2019-02-12 14:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"595880":{"id":"595880","type":"image","title":"Petit Institute Breakfast Club Seminar Series","body":null,"created":"1505321122","gmt_created":"2017-09-13 16:45:22","changed":"1505321122","gmt_changed":"2017-09-13 16:45:22","alt":"","file":{"fid":"227095","name":"breakfast-club-2017.png","image_path":"\/sites\/default\/files\/images\/breakfast-club-2017.png","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/breakfast-club-2017.png","mime":"image\/png","size":4915264,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/breakfast-club-2017.png?itok=97VbcBVA"}}},"media_ids":["595880"],"related_links":[{"url":"http:\/\/people.math.gatech.edu\/~heitsch\/","title":"Heitsch profile"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"},{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"11879","name":"BK Club"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E - Events Manager\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}