{"612846":{"#nid":"612846","#data":{"type":"event","title":"PhD Defense by Nicholas A. Kovacs","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDoctor of Philosophy in Bioinformatics\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ein the School of Chemistry and Biochemistry,\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EMr. Nicholas A. Kovacs\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDefends his thesis:\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EData Mining the Structure of the Ribosome to Unravel the History of Proteins\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMonday, October 22nd, 2018 at 11:00 AM\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELocation Pending\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EProf. Loren Williams - School of Chemistry and Biochemistry (Advisor)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EProf. Nicholas Hud - School of Chemistry and Biochemistry\u003C\/p\u003E\r\n\r\n\u003Cp\u003EProf. M.G. Finn - School of Chemistry and Biochemistry\u003C\/p\u003E\r\n\r\n\u003Cp\u003EProf. King Jordan - School of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EProf. Jeffrey Skolnick - School of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EContained within every cell of every organism on Earth is a molecular fossil that has recorded the evolution of life since its origin approximately 4 billion years ago. Composed of both RNA and protein, the ribosome is the molecular tape-recorder that has logged the evolution of life within the sequences and structures of its RNA and protein. The structure of ribosomal RNA contains its evolution. We extend the model of ribosomal evolution to include ribosomal protein. The evolution of protein was guided by the ribosome, on the ribosome, and for the ribosome. Ribosomal proteins that are present in all of life today present a molecular chronology of the origins and evolution of protein. We show that partitions of ribosomal proteins reveal the history of protein folding which stretches back since the origin of life. The data support\u0026nbsp;a model in which (i) short, random coil polypeptides accreted onto the surface of the ribosome, and (ii) lengthened over time and coalesced into \u0026beta;-structures. (iii) These \u0026beta;-structures then collapsed, primarily into \u0026beta;-domains. (iv) Domains accumulated and gained complex super-secondary structures composed of both \u0026alpha;-helix and \u0026beta;-strands. Life then diversified into its 3 domains and ribosomal proteins accrued elaborations on their structures. (v) In archaea and eukarya, insertions in ribosomal proteins gave rise to internal loop protrusions from their globular domains composed of unstructured segments as well as \u0026alpha;-helices which buried into ribosomal RNA structure and made contacts with other ribosomal proteins. (vi) In eukarya, \u0026alpha;-helical extensions on the termini of ribosomal proteins gave rise to intricate ribosomal protein-ribosomal protein interactions on the surface of the ribosome.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Data Mining the Structure of the Ribosome to Unravel the History of Proteins"}],"uid":"27707","created_gmt":"2018-10-16 19:32:22","changed_gmt":"2018-10-17 15:39:09","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2018-10-22T12:00:00-04:00","event_time_end":"2018-10-22T15:00:00-04:00","event_time_end_last":"2018-10-22T15:00:00-04:00","gmt_time_start":"2018-10-22 16:00:00","gmt_time_end":"2018-10-22 19:00:00","gmt_time_end_last":"2018-10-22 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}