{"610511":{"#nid":"610511","#data":{"type":"event","title":"ChocoGen: Genetic Ancestry and Health in the Colombian Pacific","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EKing Jordan, \u003C\/strong\u003E\u003Cstrong\u003EPh.D\u003C\/strong\u003E\u003Cstrong\u003E.\u003Cbr \/\u003E\r\nGeorgia Institute of Technology\u003Cbr \/\u003E\r\nSchool of Biological Sciences\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract\u003C\/strong\u003E\u003Cbr \/\u003E\r\nThe ChocoGen research project was initiated to facilitate genomic studies of the predominantly Afro-Colombian population of Choc\u0026oacute;, a state located on Colombia\u0026#39;s Pacific coast.\u0026nbsp; The project aims to (1) characterize the genetic ancestry of the population of Choc\u0026oacute;, and (2) explore the relationship between ancestry and genetic determinants of health in the region.\u0026nbsp; We compared genome-wide patterns of genetic ancestry for Choc\u0026oacute; to six other admixed American populations, with an emphasis on a Mestizo population from the neighboring state of Antioquia.\u0026nbsp; Choc\u0026oacute; shows mostly African genetic ancestry (76%) with a nearly even split between European (13%) and Native American (11%) fractions, whereas Antioquia has primarily European ancestry (75%), followed by Native American (18%) and African (7%).\u0026nbsp; Sample donors from Choc\u0026oacute; self-identify as having more African ancestry than can be genetically inferred, as opposed to what we previously found for Antioquia, where individuals tend to overestimate levels of European ancestry.\u0026nbsp;\u0026nbsp; Despite the clear differences between Choc\u0026oacute; and Antioquia at the level of continental ancestry, the two populations show overall patterns of subcontinental ancestry that are highly similar. \u0026nbsp;We investigated the role that genetic ancestry plays in the epidemiology of type 2 diabetes (T2D) for these two Colombian populations.\u0026nbsp; Choc\u0026oacute; has significantly higher predicted genetic risk for T2D compared to Antioquia, and the elevated predicted risk for T2D in Choc\u0026oacute; is correlated with higher African ancestry. Despite its elevated predicted genetic risk, the population of Choc\u0026oacute; has a three-times lower observed T2D prevalence than Antioquia, indicating that environmental factors better explain differences in T2D outcomes for Colombia.\u0026nbsp; However, Choc\u0026oacute; has substantially lower socioeconomic status (SES) than Antioquia, which is unexpected given that low SES is widely considered to be an environmental risk factor for T2D.\u0026nbsp; Our exploration of the dietary and lifestyle factors that characterize low SES in Choc\u0026oacute; illustrates how poverty can divergently manifest as a T2D protective factor in Colombia.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Ca href=\u0022http:\/\/jordan.biology.gatech.edu\/page\/\u0022\u003EMore about the speaker\u003C\/a\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"A Biological Sciences Seminar by King Jordan, Ph.D."}],"uid":"27964","created_gmt":"2018-08-28 19:31:24","changed_gmt":"2018-08-28 19:31:24","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2018-09-06T11:55:00-04:00","event_time_end":"2018-09-06T11:55:00-04:00","event_time_end_last":"2018-09-06T11:55:00-04:00","gmt_time_start":"2018-09-06 15:55:00","gmt_time_end":"2018-09-06 15:55:00","gmt_time_end_last":"2018-09-06 15:55:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"166882","name":"School of Biological Sciences"},{"id":"14383","name":"I. King Jordan"},{"id":"5268","name":"King Jordan"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:jasmine.martin@biosci.gatech.edu\u0022\u003EJasmine Martin\u003C\/a\u003E\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}