{"60634":{"#nid":"60634","#data":{"type":"event","title":"Dinshaw J. Patel,  \u0022Structural Biology of Small RNA-mediated Gene Regulation and Methylation-mediated Epigenetic Regulation\u0022","body":[{"value":"\u003Cp\u003EDr.\nJeffrey Skolnick and the Center for the Study of Systems Biology are pleased to\nkick-off this years Distinguished Lecture Series in Systems Biology with Dr.\nDinshaw J. Patel who is the Abby Rockefeller Mauze Chair in Experimental\nTherapeutics in the Structural Biology Program at Memorial Sloan-Kettering\nCancer Institute. His seminar will be held on Tuesday, September 14, 2010 from\n11:00 AM to 12:00 PM in the Microelectronics Research Center (MIRC), Room 102.\nThe title of his talk will be \u003Cstrong\u003E\u201cStructural Biology of Small RNA-mediated Gene\nRegulation and Methylation-mediated Epigenetic Regulation\u0022.\u003C\/strong\u003E\u003C\/p\u003E\n\n\n\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E The\nfirst part of the lecture will focus on the structural biology of riboswitches,\nmRNA elements consisting of a sensing domain and an expression platform, that\nundergo conformational changes on metabolite binding, and utilize on-off\nswitches to control gene expression. The lecture will next describe recent\nresearch on the structural biology of argonaute proteins, their binary complex\nwith guide strand and ternary complex with added target strand, thereby\nproviding insights into nucleation, propagation and cleavage events associated\nwith RNA silencing. The second part of the lecture will focus on recognition\nevents controlling epigenetic regulation mediated by methylation marks on\nhistone tails and at CpG steps on DNA. The lecture will describe the\nrecognition principles that allow the jumenji family histone lysine demethylase\nJHDM1A to site-specifically demethylate lower methylation states of histone H3\nmethylated at lysine 36. The lecture will next describe the recently determined\nstructure of an autoinhibitory DNMT1-DNA complex, thereby formulating a\ntwo-state model of eukaryotic maintenanace DNA methylation. \u003C\/p\u003E\n\n\u003Cp\u003EDr.\nPatel\u0027s group applies crystallographic and solution NMR techniques to\ninvestigate macromolecular-mediated recognition, regulation and catalysis. The\nmajor thrust of the laboratory is currently in the structural biology of RNA\nsilencing and the histone\/epigenetics code. Significant efforts are also\nunderway towards a molecular understanding of RNA-mediated events involving\nriboswitches and ribozymes, as well as protein-RNA recognition events impacting\non disease syndromes. Other projects include higher order DNA architectures\nwith an emphasis on DNA quadruplexes, and the replication of DNA damage sites\nby bypass polymerases. Finally, our group also studies the molecular basis of\nglycosphingolipid binding specificity.\u003C\/p\u003E\u003Cp\u003ECSSB Distinguished Lecture Series: Fall 2010\u003Cbr \/\u003E09\/14\/2010 - Dinshaw J. Patel, Memorial Sloan-Kettering Cancer Institute\u003Cbr \/\u003E09\/21\/2010 - Andrea Califano, Columbia University\u003Cbr \/\u003E10\/12\/2010 - Bruce Berne, Columbia University\u003Cbr \/\u003E10\/26\/2010 - Gary Siuzdak, The Scripps Research Institute\u003Cbr \/\u003E11\/09\/2010 - Charles Cantor, Boston University\u003Cbr \/\u003E11\/11\/2010 - Kristin Brown, GlaxoSmithKline\u003Cbr \/\u003E11\/30\/2010 - JoAnne Stubbe, MIT\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Dr. Jeffrey Skolnick and the Center for the Study of Systems Biology are pleased to kick-off this years Distinguished Lecture Series in Systems Biology with Dr. Dinshaw J. Patel fromMemorial Sloan-Kettering Cancer Institute."}],"uid":"27199","created_gmt":"2010-08-26 14:44:39","changed_gmt":"2016-10-08 01:52:11","author":"Jessica Forness","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2010-09-14T12:00:00-04:00","event_time_end":"2010-09-14T13:00:00-04:00","event_time_end_last":"2010-09-14T13:00:00-04:00","gmt_time_start":"2010-09-14 16:00:00","gmt_time_end":"2010-09-14 17:00:00","gmt_time_end_last":"2010-09-14 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":["free_food"],"related_links":[{"url":"http:\/\/www.mskcc.org\/mskcc\/html\/11814.cfm","title":"Faculty Webpage"}],"groups":[{"id":"1182","name":"General"},{"id":"1275","name":"School of Biological Sciences"},{"id":"1278","name":"College of Sciences"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EJessica Gilmore Forness\u003Cbr \/\u003ECenter Manager\u003Cbr \/\u003ECenter for the Study of Systems Biology\u003Cbr \/\u003EPhone: (404) 407-8976 \u003Cbr \/\u003EE-mail: \n\u003Ca href=\u0022mailto:jessica.gilmore@biology.gatech.edu\u0022\u003Ejessica.gilmore@biology.gatech.edu\u003C\/a\u003E\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/cssb.biology.gatech.edu\/\u0022 title=\u0022http:\/\/cssb.biology.gatech.edu\/\u0022\u003Ehttp:\/\/cssb.biology.gatech.edu\/\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}