{"648423":{"#nid":"648423","#data":{"type":"event","title":"Nano@Tech Fall 2022 Series | Molecular Archives: High-Density Digital Data Storage with DNA","body":[{"value":"\u003Ch4\u003ENicholas Guise | Senior Research Scientist; Georgia Tech Research Institute\u003C\/h4\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract: \u003C\/strong\u003E Exponential increases in digital data production are rapidly outpacing improvements in cost and density of conventional magnetic storage media. Large industry and government entities now routinely need to archive digital data at the Exabyte scale, at five-year storage and maintenance costs approaching $100M. Encoding data in synthetic DNA offers the potential for deployable storage technologies that can eventually scale into the Exabyte regime and beyond, with substantially reduced physical footprint, power, and cost requirements relative to magnetic tape or hard drives. Existing implementations of DNA data storage are limited to small file sizes and boutique applications such as time capsules. The SMASH program is an IARPA-funded effort aimed at demonstrating commercially relevant data storage volumes and costs, in order to open large archival applications and attract further investment from private industry. GTRI is leading a team of partners from the biotech industry (Twist Bioscience, Roswell Biotechnologies) to develop scalable technologies for DNA data read\/write operations. At Georgia Tech, the SMASH team is producing nanofabricated \u0026ldquo;DNA microchips\u0026rdquo; for massively parallel synthesis of DNA, combining new techniques from synthetic biology with the proven manufacturability and scalability of CMOS control electronics.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBio:\u003C\/strong\u003E Dr. Nicholas Guise is a Senior Research Scientist and Associate Chief of the Quantum Systems Division at GTRI. Dr. Guise obtained his Ph.D. in Physics from Harvard University and completed an NRC postdoctoral fellowship in the atomic spectroscopy group at the National Institute of Standards and Technology (NIST). At GTRI, Dr. Guise has led research programs in secure quantum communications, scalable quantum computing with microfabricated ion traps, and molecular information storage. He currently serves as PD\/PI for the SMASH (Scalable Molecular Archival Software and Hardware) program, an interdisciplinary IARPA-funded effort towards large-scale storage of digital data in synthetic DNA, leading a team that spans academia and the biotech industry.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Featuring Nicholas Guise Ph.D. | Quantum Systems Division, Georgia Tech Research Institute"}],"uid":"27863","created_gmt":"2021-06-29 13:09:48","changed_gmt":"2021-09-24 13:35:57","author":"Christa Ernst","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2021-09-28T13:00:00-04:00","event_time_end":"2021-09-28T14:00:00-04:00","event_time_end_last":"2021-09-28T14:00:00-04:00","gmt_time_start":"2021-09-28 17:00:00","gmt_time_end":"2021-09-28 18:00:00","gmt_time_end_last":"2021-09-28 18:00:00","rrule":null,"timezone":"America\/New_York"},"extras":["free_food"],"groups":[{"id":"217141","name":"Georgia Tech Materials Institute"},{"id":"545781","name":"Institute for Data Engineering and Science"},{"id":"197261","name":"Institute for Electronics and Nanotechnology"},{"id":"1271","name":"NanoTECH"}],"categories":[],"keywords":[{"id":"187433","name":"go-ien"},{"id":"187582","name":"go-ibb"},{"id":"2463","name":"electro optics"},{"id":"188193","name":"DNA storage"},{"id":"12701","name":"Institute for Electronics and Nanotechnology"},{"id":"176933","name":"go-cmat"},{"id":"187023","name":"go-data"},{"id":"186870","name":"go-imat"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"177814","name":"Postdoc"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003Edavid.gottfried@ien.gatech.edu\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}},"601231":{"#nid":"601231","#data":{"type":"event","title":"Cell Manufacturing Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0026ldquo;Near Infrared and Short Wave Radio Frequency Sensors for Wireless Biomanufacturing Process Analytics\u0026rdquo;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ENigel Reuel, Ph.D.\u003Cbr \/\u003E\r\nAssistant Professor\u003Cbr \/\u003E\r\nDepartment of Chemical and Biological Engineering\u003Cbr \/\u003E\r\nIowa State University\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EOne pressing problem for manufacturing cell and protein based therapies are suitable sensors for process monitoring and control.\u0026nbsp; Desired features are the ability to make measurements real-time, in-line, and without breaking the sterile environment.\u0026nbsp; The Reuel Group at Iowa State University researches methods of contact free measurement systems in closed environments (bioreactors, soil systems, bandages, etc.).\u0026nbsp; This is done with transducers that broadcast in frequency bands suitable for water and plastic penetration.\u0026nbsp; In this talk I will detail our work on 1) optical nanotransducers that fluoresce in the near infrared (900-1000nm) and 2) mesoscale resonators that resonate in the short wave radio frequency band (1-100MHz).\u0026nbsp; In both cases the transducer is rendered selective to a desired analyte by coating it with a selective agent that either promotes binding or undergoes a conformational change upon interaction.\u0026nbsp; When the target cell or protein interacts with the sensor surface, there is a frequency modulation that can be monitored from a distance.\u0026nbsp; The final results of hydrolytic enzyme activity characterization and ion concentration measurement as well as preliminary results for protein and cell binding assays using these two sensors will be presented to demonstrate their potential.\u0026nbsp;\u0026nbsp; Their utility for media composition, cell viability, and cell potency monitoring will be discussed.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EThis presentation can be seen via videoconference using BlueJeans:\u003Cbr \/\u003E\r\nhttps:\/\/bluejeans.com\/435290867\u003C\/em\u003E\u003C\/strong\u003E\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"\u201cNear Infrared and Short Wave Radio Frequency  Sensors for Wireless Biomanufacturing  Process Analytics\u201d - Nigel Reuel, Ph.D. Iowa State University "}],"uid":"27349","created_gmt":"2018-01-23 20:42:28","changed_gmt":"2018-05-07 13:55:08","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2018-05-21T10:30:00-04:00","event_time_end":"2018-05-21T11:30:00-04:00","event_time_end_last":"2018-05-21T11:30:00-04:00","gmt_time_start":"2018-05-21 14:30:00","gmt_time_end":"2018-05-21 15:30:00","gmt_time_end_last":"2018-05-21 15:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.cbe.iastate.edu\/the-department\/facultystaff\/?user_page=reuel","title":"Reuel profile"},{"url":"http:\/\/cellmanufacturingusa.org","title":"CMaT"},{"url":"http:\/\/www.cellmanufacturing.gatech.edu","title":"M3CM"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"126571","name":"go-PetitInstitute"},{"id":"176933","name":"go-cmat"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:ravi.kane@chbe.gatech.edu\u0022 target=\u0022_blank\u0022\u003ERavi Kane, Ph.D.\u003C\/a\u003E - faculty host\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}