{"60128":{"#nid":"60128","#data":{"type":"news","title":"Staring (cell) death in the face: imaging agents for necrotic cells","body":[{"value":"\u003Cp\u003EDNA usually occupies a privileged place inside the cell. Although cells in our body die all the time, an orderly process of disassembly (programmed cell death or apoptosis) generally keeps cellular DNA from leaking all over the place. DNA\u2019s presence outside the cell means something is wrong: tissue injury has occurred and cells are undergoing necrosis.\n\u003C\/p\u003E\n\u003Cp\u003EResearchers from the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University have devised a way to exploit the properties of extracellular DNA to create an imaging agent for injured tissue. Niren Murthy and Mike Davis recently published a paper in Organic Letters describing the creation of \u201cHoechst-IR.\u201d This imaging agent essentially consists of the DNA-binding compound Hoechst 33258 (often used to stain cells before microscopy), attached to a dye that is visible in the near-infrared range. A water-loving polymer chain between the two keeps the new molecule from crossing cell membranes and binding DNA inside the cell.\n\u003C\/p\u003E\n\u003Cp\u003E\u003Ca href=\u0027http:\/\/www.emoryhealthsciblog.com\/?p=2668\u0027\u003EClick to view full article\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Researchers from the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University have devised a way to exploit the properties of extracellular DNA to create an imaging agent for injured tissue.","format":"limited_html"}],"field_summary_sentence":[{"value":"Staring (cell) death in the face: imaging agents for necrotic ce"}],"uid":"27349","created_gmt":"2010-07-20 00:00:00","changed_gmt":"2016-10-08 03:07:11","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2010-07-19T00:00:00-04:00","iso_date":"2010-07-19T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"134","name":"Student and Faculty"}],"keywords":[{"id":"10298","name":"BME Niren Murthy"},{"id":"2305","name":"Emory University"},{"id":"10297","name":"Geirgia Tech"},{"id":"248","name":"IBB"},{"id":"10299","name":"Mike Davis"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EFloyd Wood\u003C\/strong\u003E\u003Cbr \/\u003EIBB\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=fwood3\u0022\u003EContact Floyd Wood\u003C\/a\u003E","format":"limited_html"}],"email":["floyd.wood@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}