{"599234":{"#nid":"599234","#data":{"type":"event","title":"Probing the function of Chromatin Remodeling Factors with Biomolecular Simulations","body":[{"value":"\u003Ch3\u003ESchool of Physics Soft Condensed Matter \u0026amp; Physics of Living Systems Seminar:\u0026nbsp;Prof. Jeff Wereszczynski, Illinois Institute of Technology\u003C\/h3\u003E\r\n\r\n\u003Cp\u003EEukaryotes package and maintain their genetic code in chromatin fibers. The fundamental unit of chromatin is the nucleosome, a complex of approximately equal mass of protein and DNA molecules.\u0026nbsp; By altering the physical and biochemical properties of the nucleosome, the cell regulates the structure and stability of chromatin and thus tunes gene expression.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;In this talk, I will discuss efforts by our group to use molecular dynamics simulations in conjunction with data from NMR, SAXS, and Cryo-EM experiments to understand the processes by which chromatin remodeling factors alter the structure and dynamics of single and poly-nucleosomal arrays.\u0026nbsp; I will focus on the effects of histone variants, post-translational modifications, and linker histones.\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EIn addition, I will discuss how we can use Bayesian inference to rigorously determine a minimal ensemble of states of flexible biomolecular complexes to describe the results of small angle X-ray scattering experiments from enhanced sampling simulations. \u0026nbsp;\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Probing the function of Chromatin Remodeling Factors with Biomolecular Simulations"}],"uid":"30957","created_gmt":"2017-11-28 22:02:41","changed_gmt":"2017-11-28 22:19:45","author":"Shaun Ashley","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-12-13T15:00:00-05:00","event_time_end":"2017-12-13T16:00:00-05:00","event_time_end_last":"2017-12-13T16:00:00-05:00","gmt_time_start":"2017-12-13 20:00:00","gmt_time_end":"2017-12-13 21:00:00","gmt_time_end_last":"2017-12-13 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"599235":{"id":"599235","type":"image","title":"Jeff Wereszcznski","body":null,"created":"1511906685","gmt_created":"2017-11-28 22:04:45","changed":"1511906685","gmt_changed":"2017-11-28 22:04:45","alt":"","file":{"fid":"228444","name":"Jeff Wereszczynski pic.jpg","image_path":"\/sites\/default\/files\/images\/Jeff%20Wereszczynski%20pic.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/Jeff%20Wereszczynski%20pic.jpg","mime":"image\/jpeg","size":7237,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/Jeff%20Wereszczynski%20pic.jpg?itok=l6a4qdtN"}}},"media_ids":["599235"],"groups":[{"id":"126011","name":"School of Physics"}],"categories":[],"keywords":[{"id":"960","name":"physics"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003Eshaun.ashley@physics.gatech.edu\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}