{"599173":{"#nid":"599173","#data":{"type":"event","title":"PhD Proposal by Jiexi Liao","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EJiexi Liao\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u003Cem\u003EBME PhD Proposal\u003C\/em\u003E\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003E\u0026nbsp;\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDecember 14, 2017, 9-11 AM\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMcIntire Conference Room (3115), Whitaker Building\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAdvisor: Cheng Zhu, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EGeorgia Institute of Technology, Department of Biomedical Engineering\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EShuichi Takayama, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EGeorgia Institute of Technology, Department of Biomedical Engineering\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EManu O. Platt, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EGeorgia Institute of Technology, Department of Biomedical Engineering\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBrian G. Petrich, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EEmory University, Department of Pediatrics\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EShaun P. Jackson, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cem\u003EUniversity of Sydney, Heart Research Institute\u003C\/em\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMechanically regulated hyper-reactivity of platelets in diabetes: a close look at binding-signaling-binding\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDiabetes affects 422 million people globally and the prevalence is growing. Cardiovascular complications from atherothrombosis are the primary cause\u0026nbsp;of diabetes-related death largely due to the exaggerated thrombotic response. Diabetic\u0026nbsp;patients are typically less responsive to conventional anti-coagulant and anti-platelet therapies that target the biochemical pathways of thrombosis, which further increases the risk of morbidity and mortality. Evidence suggests that biomechanical pathways of platelets are markedly dysregulated in diabetes. This proposal aims to identify and characterize key players in the platelet mechanotransduction loop (binding-signaling-binding) and how their functional balance might be tipped in diabetes. Mechanosensors, such as GPIb and integrin GPIIbIIIa on platelets, can upregulate secondary messengers when binding to ligand under shear; the secondary messengers may initiate signaling cascade that would induce talin, a cytoplasmic adaptor protein, to link cytoskeleton to and activate integrins, resulting in platelet activation. The working hypotheses are 1) diabetic platelets, through GPIIbIIIa mechanosensing, are more reactive to increasing mechanical stimuli, and 2) the shear modulation of cGMP, a generally anti-thrombotic secondary messenger, is dysfunctional in diabetes, and 3) platelet talin is dysregulated in diabetes; disruption of interactions between the talin head and integrin GPIIbIIIa tail that are crucial for platelet adhesion and aggregation could eliminate the phenotype of diabetic platelets.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Mechanically regulated hyper-reactivity of platelets in diabetes: a close look at binding-signaling-binding"}],"uid":"27707","created_gmt":"2017-11-27 19:11:17","changed_gmt":"2017-11-27 19:11:17","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-12-14T09:00:00-05:00","event_time_end":"2017-12-14T11:00:00-05:00","event_time_end_last":"2017-12-14T11:00:00-05:00","gmt_time_start":"2017-12-14 14:00:00","gmt_time_end":"2017-12-14 16:00:00","gmt_time_end_last":"2017-12-14 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}