{"598102":{"#nid":"598102","#data":{"type":"event","title":"PhD Defense by Lu Wang","body":[{"value":"\u003Cp\u003EIn partial fulfillment of the requirements for the degree of\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDoctor of Philosophy in Bioinformatics\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ein the\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELu Wang\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ewill defend her thesis\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETransposable Element Polymorphism and Human Genome Regulation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMonday, November 6\u003Csup\u003Eth\u003C\/sup\u003E, 2017\u003C\/p\u003E\r\n\r\n\u003Cp\u003E3:00 PM\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEngineered Biosystems Building, Children\u0026#39;s Healthcare of Atlanta Seminar Room (EBB 1005)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EThesis Advisor:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. King Jordan\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Greg Gibson\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Victoria Lunyak\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAelan Cell Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESan Francisco, CA\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. John McDonald\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Fredrik Vannberg\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESchool of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EA large proportion of the human genome is derived from transposable element (TE) sequences. TE sequences derived sequences have been shown to contribute to the regulation of the human genome in a variety of ways.\u0026nbsp; Despite that many of the known TE-derived regulatory sequences correspond to relatively ancient insertions, which are fixed across human populations, there are several active families of TEs, including the Alu, LINE-1, and SVA retrotransposons that can mobilize via reverse transcription of RNA intermediates. Germline transposition of the active retrotransposons generates polymorphisms between individuals, and somatic transposition generates cellular heterogeneity. Given the disruptive potential of TE insertions, along with the regulatory potential of TE-derived sequences, one may expect a complex interplay between TE insertion polymorphisms and inter-individual differences in the expression of human genes, as well as TE activities and the host regulatory mechanisms. My work has been focusing on the role of polymorphic TEs (polyTE) in the regulation of the genes and how the human genome regulates TE activities. Genome-wide association screens were also performed to evaluate the extent to which recent TE activity could lead to regulatory polymorphisms among populations. TE insertion polymorphisms were also related to common health and disease phenotypes that have been previously interrogated through genome-wide association studies (GWAS). Lastly, the genome-wide association screen approach has also been applied to search for potential modifiers of TE activities. Numerous human polyTE insertion sites were identified as \u003Cem\u003Ecis\u003C\/em\u003E and \u003Cem\u003Etrans\u003C\/em\u003E expression quantitative trait loci (eQTL). Their regulatory effects were shown to directly related to cell type-specific function in the immune system. Two polyTE loci that are co-located with cell type-specific enhancers were linked to common diseases phenotypes. Both known and putative modifiers of TE expression were identified through the joint analysis of L1 and gene eQTLs. In summary, the results showed that the human genome regulates TE activities through different pathways and that polyTE could impact human health and disease phenotypes by causing changes in gene expression.\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Transposable Element Polymorphism and Human Genome Regulation"}],"uid":"27707","created_gmt":"2017-10-30 19:07:46","changed_gmt":"2017-10-30 19:07:46","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-11-06T15:00:00-05:00","event_time_end":"2017-11-06T17:00:00-05:00","event_time_end_last":"2017-11-06T17:00:00-05:00","gmt_time_start":"2017-11-06 20:00:00","gmt_time_end":"2017-11-06 22:00:00","gmt_time_end_last":"2017-11-06 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}