{"597578":{"#nid":"597578","#data":{"type":"event","title":"PhD Proposal by Jiahui Zhang","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EJiahui\u0026nbsp;Zhang\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME PhD\u0026nbsp;Proposal Presentation\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate:\u003C\/strong\u003E\u0026nbsp;Wednesday, November 1st, 2017\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETime:\u003C\/strong\u003E\u0026nbsp;10:00 AM\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation:\u003C\/strong\u003E\u0026nbsp;Manufacturing Related Disciplines Complex (MRDC), Room 2405\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEilaf Egap, PhD (Advisor)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EHanjoong Jo, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EKrishnendu Roy, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003EYounan Xia, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003ESeth Marder, PhD\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle:\u003C\/strong\u003E\u0026nbsp;NIR-II Fluorescence Imaging of Atherosclerosis with Organic Semiconducting Nanoparticles\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAtherosclerosis is the leading cause of death worldwide, but is usually diagnosed at very late stage, since it may not cause symptoms until the arteries are severely narrowed. Thus, developing a targeted imaging strategy to detect atherosclerosis at earlier stage of the disease is important. Since atherosclerosis is a progressive inflammatory disease, we can utilize targeting inflammatory markers to selectively target endothelial dysfunction and early plaques. Fluorescence imaging in the second near-infrared window (NIR-II, 1000 nm-1700 nm) is an emerging technology that benefit from deeper tissue penetration compared with fluorescence imaging in the traditional near-infrared window (NIR-I, 700 nm-1000 nm) due to reduced photon scattering and tissue autofluorescence, and thus show a great potential for diagnosis and assessment of atherosclerosis. Donor-acceptor-donor (D-A-D) type semiconducting small molecules with reduced band-gap are a promising class of organic NIR-II emitting fluorophores that are in favor of clinical translation compared to their inorganic counterpart. Therefore,\u0026nbsp;we propose to detect and image atherosclerosis plaques and inflamed endothelium using non-targeted or targeted nanoparticles composed of organic semiconducting small molecules with NIR-II fluorescence imaging.\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003EPreliminary results showed that NIR-II emitting D-A-D type molecules-encapsulated nanoparticles could passively accumulate in atherosclerotic plaques and be imaged\u0026nbsp;\u003Cem\u003Eex vivo.\u0026nbsp;\u003C\/em\u003EFunctionalized nanoparticles with a VCAM-1-internalizing peptide could specifically label inflamed endothelial cells both\u0026nbsp;\u003Cem\u003Ein vitro\u003C\/em\u003E\u0026nbsp;and\u0026nbsp;\u003Cem\u003Ein vivo\u003C\/em\u003E. Further research will be conducted to assess the possibility of detecting endothelial dysfunction and atherosclerotic plaques\u003Cem\u003E\u0026nbsp;in vivo\u003C\/em\u003E\u0026nbsp;with NIR-II imaging utilizing these nanoparticles as contrast agents.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"NIR-II Fluorescence Imaging of Atherosclerosis with Organic Semiconducting Nanoparticles"}],"uid":"27707","created_gmt":"2017-10-18 19:46:12","changed_gmt":"2017-10-27 17:26:57","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-11-01T11:00:00-04:00","event_time_end":"2017-11-01T13:00:00-04:00","event_time_end_last":"2017-11-01T13:00:00-04:00","gmt_time_start":"2017-11-01 15:00:00","gmt_time_end":"2017-11-01 17:00:00","gmt_time_end_last":"2017-11-01 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}