{"592384":{"#nid":"592384","#data":{"type":"event","title":"PhD PRoposal by Marissa Ruehle","body":[{"value":"\u003Cp\u003EMarissa Ruehle\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPhD Proposal Presentation\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDate: Thursday, June 8th\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETime: 10:30 AM\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELocation: EBB\u0026nbsp;CHOA seminar room\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAdvisors:\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Robert Guldberg\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Nick Willett\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThesis Committee:\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Joel Boerckel\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Andres Garcia\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Jay Hoying\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Rebecca Levit\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETitle: Cell-Based Vascular Therapeutics for Enhanced Bone Regeneration\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAbstract:\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBone is a highly vascularized tissue, and adequate vascularity is an essential requirement for proper bone healing. Vascularity is a challenge in critical-sized defects, especially those with concomitant muscle damage typical of traumatic injury. The Gustilo Classification system scores open fractures from I to IIIC in order of increasing severity, increasing complication rate, and increasing patient morbidity. The hallmark of the most severe class IIIC injuries is the presence of vascular damage. These patients heal slowly and exhibit higher rates of infection and non-union, underscoring the critical importance of vasculature to bone healing. Additionally, the bone defect environment is a complex niche, involving mechanical cues in addition to a host of chemical signals. It is well known that mechanical loading affects bone growth and remodeling, and while flow-mediated mechanics influence the vasculature, effects of bulk matrix deformation are not well understood. To most effectively leverage the use of a vascular therapeutic in this space, we must better understand the effect of the relevant mechanical loading environment on the vasculature. Microvascular fragments (MVF), multicellular structures derived from mature vasculature, form networks \u003Cem\u003Ein vitro\u003C\/em\u003E and anastamose with the host vasculature when implanted \u003Cem\u003Ein vivo\u003C\/em\u003E. As such, they are a useful \u003Cem\u003Ein vitro \u003C\/em\u003Emodel of mature vasculature and may be a viable therapeutic candidate. Stromal vascular fraction (SVF) is a single cell digestion of mature vasculature that also forms networks \u003Cem\u003Ein vitro\u003C\/em\u003E and has been used as an \u003Cem\u003Ein vivo\u003C\/em\u003E therapeutic.\u0026nbsp;The \u003Cstrong\u003Eoverall objective\u003C\/strong\u003E of this thesis is to increase understanding of mechanical effects on vascular growth in order to engineer a cell-based vascular therapeutic for enhanced bone regeneration. The \u003Cstrong\u003Eoverarching hypothesis\u003C\/strong\u003E is that cell source, material delivery vehicle, and mechanical environment each influence the efficacy of a vascular therapeutic for critical-sized bone defects.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":": Cell-Based Vascular Therapeutics for Enhanced Bone Regeneration"}],"uid":"27707","created_gmt":"2017-06-02 15:35:01","changed_gmt":"2017-06-02 15:36:35","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-06-08T11:30:00-04:00","event_time_end":"2017-06-08T13:30:00-04:00","event_time_end_last":"2017-06-08T13:30:00-04:00","gmt_time_start":"2017-06-08 15:30:00","gmt_time_end":"2017-06-08 17:30:00","gmt_time_end_last":"2017-06-08 17:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}