{"590561":{"#nid":"590561","#data":{"type":"event","title":"PhD Proposal by Riley T. Zeller-Townson","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ERiley T. Zeller-Townson\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME Ph.D. Proposal Presentation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDate: Friday, April 28th 2017\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETime: 10:00 AM\u003C\/p\u003E\r\n\r\n\u003Cp\u003ELocation:\u0026nbsp;McIntire Conference room- Whitaker 3115\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAdvisor:\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Rob Butera\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThesis Committee:\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Garrett Stanley\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Chris Rozell\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Morten Raastad\u003C\/p\u003E\r\n\r\n\u003Cp\u003EDr. Bilal Haider\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETitle:\u0026nbsp;MECHANISMS OF HIGH-VARIANCE CONDUCTION IN THE AXON\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EAbstract:\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe conduction of action potentials along the axon is taught to be reliable, consistent, and fast, with conduction failures dogmatically studied at the synapse.\u0026nbsp; However, measurements of action potential conduction both in vitro and in vivo suggest that conduction can transition into a state of high trial-to-trial variability and low reliability.\u0026nbsp; This unreliable conduction occurs along the axon, not at the synapse, and its mechanism is unknown.\u0026nbsp; Finding this mechanism would help determine the limits of axon conduction fidelity, and may shed light on the effects of clinical electrical stimulation on the nervous system. \u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003EPreliminary results suggest that the high-variance state is inherently a multi-compartment phenomenon, requiring electrophysiology tools with the capacity for single-trial recording of axonal action potentials at multiple locations, over thousands of trials. CMOS-based high density micro-electrode arrays will be used to 1) locate the sources of this variance, 2) compare variability in naturalistic and stimulus evoked propagation, and 3) test possible underlying biophysical mechanisms.\u0026nbsp; This study will bridge gaps between the study of repeated electrical stimulation of neurons, activity-dependent conduction velocity, and homeostatic control of axon signaling. \u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"MECHANISMS OF HIGH-VARIANCE CONDUCTION IN THE AXON"}],"uid":"27707","created_gmt":"2017-04-18 14:20:14","changed_gmt":"2017-04-18 14:20:14","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-04-28T11:00:00-04:00","event_time_end":"2017-04-28T13:00:00-04:00","event_time_end_last":"2017-04-28T13:00:00-04:00","gmt_time_start":"2017-04-28 15:00:00","gmt_time_end":"2017-04-28 17:00:00","gmt_time_end_last":"2017-04-28 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"78751","name":"Undergraduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}