{"588502":{"#nid":"588502","#data":{"type":"event","title":"Integrated Cancer Research Center Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0026quot;Decoding the Non-coding RNAs in Ovarian Cancer\u0026quot;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDanny N. Dhanasekaran, Ph.D.\u003Cbr \/\u003E\r\nProfessor, Department of Cell Biology\u003Cbr \/\u003E\r\nDirector, Center for Basic Cancer Research\u003Cbr \/\u003E\r\nDeputy Director for Basic Research\u003Cbr \/\u003E\r\nUniversity of Oklahoma, Cancer Institute\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EOvarian cancer mortality is primarily due to late diagnosis of the disease and therapy resistance that lead to cancer recurrence. Our research is focused on identifying genetic and epigenetic mechanisms underlying ovarian cancer progression and recurrence. Recently, we identified the upregulation of UCA1, an oncogenic long non-coding RNA in ovarian cancer cells and issues. In addition to identifying the possible oncogenic mechanism mediated by UCA1, we observed that the inhibition of UCA1 could attenuate ovarian cancer growth. Our studies also point to UCA1 as a lncRNA signature that can\u0026nbsp;\u003Cbr \/\u003E\r\nindicate therapy resistance. A global analysis of differentially expressed genes in ovarian cancer cells indicate the increased expression of several lncRNAs in ovarian cancer cells compared to normal ovarian surface epithelial or fallopian tube-derived epithelial cells. Co-expression network analysis of lncRNAs and mRNA identify several regulatory loops targeted by lncRNAs in controlling gene expression. Further characterization of these ovarian cancer specific lncRNAs should lead to the development of novel diagnostic, prognostic, and\/or therapeutic agents for ovarian cancer.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"\u201cDecodoing the Non-coding RNAs in Ovarian  Cancer\u201d - Danny Dhanasekaran, Ph.D. - University of Oklahoma"}],"uid":"27349","created_gmt":"2017-03-09 17:10:24","changed_gmt":"2017-04-13 21:12:26","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-03-14T17:00:00-04:00","event_time_end":"2017-03-14T18:00:00-04:00","event_time_end_last":"2017-03-14T18:00:00-04:00","gmt_time_start":"2017-03-14 21:00:00","gmt_time_end":"2017-03-14 22:00:00","gmt_time_end_last":"2017-03-14 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"https:\/\/www.oumedicine.com\/department-of-cell-biology\/general-program-info\/faculty\/danny-n-dhanasekaran","title":"Dhanasekaran profile"},{"url":"http:\/\/icrc.gatech.edu","title":"Integrated Cancer Research Center"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"168803","name":"go-icrc-events"},{"id":"172695","name":"go-icrc"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78761","name":"Faculty\/Staff"},{"id":"78751","name":"Undergraduate students"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:john.mcdonald@biology.gatech.edu\u0022\u003EJohn McDonald\u003C\/a\u003E - faculty host\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}