{"587447":{"#nid":"587447","#data":{"type":"event","title":"PhD Proposal by Joshua R. Jarrell","body":[{"value":"\u003Cp\u003EDoctoral Thesis Proposal\u003C\/p\u003E\r\n\r\n\u003Cp\u003EGeorgia Institute of Technology, School of Biological Sciences\u003C\/p\u003E\r\n\r\n\u003Cp\u003EFebruary 27, 2017, 3:00pm, Room 1253, 555 14th St NW\u003C\/p\u003E\r\n\r\n\u003Cp\u003EJoshua R. Jarrell\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle: \u003C\/strong\u003EQuadrupedal locomotion with a unilateral bone-anchored transtibial prosthesis in the cat\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee Members: \u003C\/strong\u003EBoris I. Prilutsky, Ph.D. (Advisor); T. Richard Nichols, Ph.D.; Johnna S.\u003C\/p\u003E\r\n\r\n\u003Cp\u003ETemenoff, Ph.D.; Young-Hui Chang, Ph.D.; and W. Lee Childers, Ph.D.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EBone-anchored limb prostheses offer numerous advantages over conventional socket-supported\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eprostheses. Loads on a bone-anchored prosthetic limb during natural activities are directly\u003C\/p\u003E\r\n\r\n\u003Cp\u003Etransmitted to the residual bone that prevents damage of skin and other soft tissues in the case of\u003C\/p\u003E\r\n\r\n\u003Cp\u003Esocket prostheses. Despite this and other documented advantages, however, bone-anchored\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eprostheses have been limited in their availability in the United States due to an increased risk of\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eskin and deep tissue infection through the skin-implant interface. A novel porous titanium pylon,\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ethe skin- and bone-integrating pylon (SBIP), has been developed to promote deeper tissue\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eintegration with the percutaneous implant and thereby reduce the risk of infection (Pitkin et al.,\u003C\/p\u003E\r\n\r\n\u003Cp\u003E2009; Pitkin and Raykhtsaum, 2012; Farrell et al., 2014). Further research is needed to examine\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eif the SBIP can be utilized for anchoring limb prosthesis in natural load bearing applications. In\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eveterinary medicine, gait changes in animals after limb loss and subsequent prosthesis\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eintervention have not been extensively investigated. In addition, it is not completely understood\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ehow the motor system adapts to a loss of sensory feedback from the distal leg and to a reduced\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eability to absorb and generate mechanical energy for locomotion. Currently, detailed\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ebiomechanical analyses of such adaptations are missing. Therefore, \u003Cstrong\u003Ethe overall goal of the\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003Estudy is to examine if or how the motor system adapts to a unilateral, transtibial SBIPanchored\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003Eprostheses during locomotion in the cat. \u003C\/strong\u003EThe general hypothesis to be tested is that\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ethe SBIP will provide secure, infection free anchoring of a transtibial prosthesis and that will\u003C\/p\u003E\r\n\r\n\u003Cp\u003Epermit the cats to adopt the prosthesis for stable quadrupedal locomotion. In \u003Cstrong\u003ESpecific Aim 1 \u003C\/strong\u003EI\u003C\/p\u003E\r\n\r\n\u003Cp\u003Ewill examine the ability of the SBIP to serve as attachment for a unilateral, transtibial boneanchored\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eprostheses during walking in the cat. In \u003Cstrong\u003ESpecific Aim 2 \u003C\/strong\u003EI will determine the amount of\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eskin and bone ingrowth into the SBIP after the residual tibia has been loaded during natural\u003C\/p\u003E\r\n\r\n\u003Cp\u003Emotor activities including locomotion. In \u003Cstrong\u003ESpecific Aim 3 \u003C\/strong\u003EI will determine margins of static and\u003C\/p\u003E\r\n\r\n\u003Cp\u003Edynamic stability during quadrupedal walking with a unilateral bone-anchored passive transtibial\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eprosthesis. This study will provide important new information about the ability of the novel SBIP\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eimplant to serve for anchoring limb prostheses and about how the motor system of a quadrupedal\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eanimal adapts to a partial loss of afferent sensory feedback and the ability to generate mechanical\u003C\/p\u003E\r\n\r\n\u003Cp\u003Eenergy for locomotion.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Quadrupedal locomotion with a unilateral bone anchored transtibal prosthesis in the cat"}],"uid":"27707","created_gmt":"2017-02-14 21:31:26","changed_gmt":"2017-02-14 21:31:26","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-02-27T15:00:00-05:00","event_time_end":"2017-02-27T17:00:00-05:00","event_time_end_last":"2017-02-27T17:00:00-05:00","gmt_time_start":"2017-02-27 20:00:00","gmt_time_end":"2017-02-27 22:00:00","gmt_time_end_last":"2017-02-27 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}