{"587276":{"#nid":"587276","#data":{"type":"event","title":"PhD Proposal by Andrew Shockey","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAndrew Shockey\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EBME PhD Thesis Proposal Presentation\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EDate and Time\u003C\/strong\u003E: Thursday, February 23rd, 4pm\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ELocation\u003C\/strong\u003E: MoSE 1201A\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ECommittee\u003C\/strong\u003E: Manu Platt (advisor)\u003C\/p\u003E\r\n\r\n\u003Cp\u003EMelissa Kemp\u003C\/p\u003E\r\n\r\n\u003Cp\u003EChristine Payne\u003C\/p\u003E\r\n\r\n\u003Cp\u003EEberhard Voit\u003C\/p\u003E\r\n\r\n\u003Cp\u003EShelly Peyton (UMass Amherst)\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ETitle\u003C\/strong\u003E: Mathematical modeling of tumor associated macrophage protease activity in breast cancer\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003EAbstract:\u0026nbsp;\u003C\/strong\u003ETumor associated macrophages (TAMs) promote tumor growth, angiogenesis and metastasis and can make up 50% of tumor mass in late-stage metastatic breast cancer. TAMs contribute to tumor progression through the release of inflammatory chemokines, growth factors and proteolytic enzymes including the cysteine cathepsins B, L, K, S and V. Cathepsins are potent catalysts of extracellular matrix (ECM) degradation, but have also been identified as regulators of cellular process that operate through the activation of signaling pathways\u0026nbsp;and the cleavage of transmembrane receptor proteins, chemokines, and cellular adhesion molecules.\u0026nbsp;Cysteine cathepsins are components of a complicated regulatory proteolytic network, which includes multiple biochemical and biomechanical stimuli, endogenous protease inhibitors and other proteases capable of activating or degrading other proteases. Development of a computational model system of the cathepsin proteolytic network, which includes intracellular feedback loops and extracellular matrix degradation by proteases secreted by tumor cells and macrophages, would expand knowledge on the coordination and complex interactions of macrophages and cancer cells and be a useful tool for developing and testing pharmaceutical cathepsin inhibitors in the future.\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Mathematical modeling of tumor associated macrophage protease activity in breast cancer"}],"uid":"27707","created_gmt":"2017-02-10 14:20:56","changed_gmt":"2017-02-10 14:20:56","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2017-02-23T16:00:00-05:00","event_time_end":"2017-02-23T18:00:00-05:00","event_time_end_last":"2017-02-23T18:00:00-05:00","gmt_time_start":"2017-02-23 21:00:00","gmt_time_end":"2017-02-23 23:00:00","gmt_time_end_last":"2017-02-23 23:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}