{"56445":{"#nid":"56445","#data":{"type":"news","title":"Video Archive - Evolutionary Role of DNA Methylation in Animal Genomes","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ESoojin Yi, PhD, Assistant Professor, School of Biology\u003C\/strong\u003E\n\u003C\/p\u003E\n\u003Cp\u003ETitle: \u003Cem\u003E\u0022Evolutionary Role of DNA Methylation in Animal Genomes\u0022\u003C\/em\u003E\n\u003C\/p\u003E\n\u003Cp\u003EDNA methylation is a primary epigenetic mechanism involved in several regulatory and developmental processes. In this talk, I will focus on the molecular evolutionary role of DNA methylation. An important property of DNA methylation is its propensity to increase specific types of point mutations. Using this property, we have developed analytical tools to investigate influence of DNA methylation on genome evolution. We show that (i) DNA methylation causes different genomic regions to follow qualitatively different molecular clocks, (ii) influence regional variability of nucleotide composition, (iii) affected evolution of vertebrate promoters. Finally, (iv) our survey shows that the influence of DNA methylation on genome evolution is widespread in animal taxa. While the model invertebrate species Drosophila melanogaster and Caenorhabditis elegans lack DNA methylation, the genome of a social bee Apis mellifera exhibits an unmistakable signature of DNA methylation at sequence and functional level.\n\u003C\/p\u003E\n\u003Cp\u003E\u003Ca href=\u0027http:\/\/www.yilab.gatech.edu\/\u0027\u003EVisit the Yi Website\u003C\/a\u003E\n\u003C\/p\u003E\n\u003Cp\u003ETo view video:  \u003Ca href=\u0027http:\/\/smartech.gatech.edu\/handle\/1853\/27647\u0027\u003EYi - Breakfast Club Seminar\u003C\/a\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":[{"value":"Soojin Yi, PhD - IBB Breakfast Club Seminar"}],"field_summary":[{"value":"Soojin Yi, PhD, Assistant Professor, School of Biology\n\nTitle: \u0022Evolutionary Role of DNA Methylation in Animal Genomes\u0022","format":"limited_html"}],"field_summary_sentence":[{"value":"Video Archive - IBB Breakfast Club Seminar - Soojin Yi, PhD"}],"uid":"27195","created_gmt":"2009-04-29 00:00:00","changed_gmt":"2016-10-08 03:06:11","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2008-10-21T00:00:00-04:00","iso_date":"2008-10-21T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/smartech.gatech.edu\/handle\/1853\/27647","title":"View Video Here"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[{"id":"129","name":"Institute and Campus"},{"id":"134","name":"Student and Faculty"}],"keywords":[{"id":"277","name":"Biology"},{"id":"756","name":"Breakfast Club Seminar"},{"id":"168087","name":"Soojin Yi"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EColly Mitchell\u003C\/strong\u003E\u003Cbr \/\u003EParker H. Petit Institute for Bioengineering and Bioscience\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=cmitchell6\u0022\u003EContact Colly Mitchell\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-894-5982\u003C\/strong\u003E","format":"limited_html"}],"email":["colly.mitchell@ibb.gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}