Platelet interaction schematic

Platelet interaction schematic

A platelet interacts with the injured vascular surface at the beginning of blood clotting. The platelet uses a glycoprotein molecule to bind von Willebrand factor (VWF) to resist the dislodging force from the bloodstream. The force unfolds the domain of the molecule that binds VWF, which prolongs binding and promotes unfolding of the domain of the molecule that is close to the platelet membrane. These cooperative unfolding events lead to strong calcium signaling inside the platelet. (Credit: Yunfeng Chen, Georgia Tech)

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Categories
Life Sciences and Biology, Research
Keywords
bleeding, clotting, force measurement, mechanosensing, platelet
Status
  • Created By: John Toon
  • Workflow Status: Published
  • Created On: Aug 15, 2016 - 9:52am
  • Last Updated: Oct 7, 2016 - 10:56pm