{"56216":{"#nid":"56216","#data":{"type":"event","title":"ChBE Spring2007 Seminar Series","body":[{"value":"\u003Cp\u003EGregory T. Reeves, a Post-doc in the Department of Chemical Engineering and the Lewis-Sigler Institute of Integrative Genomics at Princeton University, presents \u003Cem\u003EModeling Chemical Kinetics: Applications from Atomic to Continuum Scale\u003C\/em\u003E as part of ChBE\u0027s spring seminar series.\n\u003C\/p\u003E\n\u003Cp\u003E* Refreshments will be served at 3:30 PM in the Lower Level 1 Gossage Atrium\u003Cbr \/\u003E\n* Lecture commences at 4:00 PM in L1255 in the Ford ES\u0026amp;T Building\n\u003C\/p\u003E\n\u003Cp\u003ESeminar Abstract\u003Cbr \/\u003E\nIn a developing organism, what begins as a single cell must give rise to diverse tissues and body\u003Cbr \/\u003E\nstructures. The pattern formation that underlies these crucial developmental processes must be\u003Cbr \/\u003E\nregulated at a variety of levels, from gene sequence to anatomy. With the growing body of\u003Cbr \/\u003E\nexperimental data, and the realization of the high degree of complexity in development,\u003Cbr \/\u003E\nmechanistic models of development have become essential for integrating data, guiding future\u003Cbr \/\u003E\nexperiments, and predicting the effects of genetic and physical experiments. However, the\u003Cbr \/\u003E\nformulation and analysis of quantitative models of development are limited by high levels of\u003Cbr \/\u003E\nuncertainty in experimental measurements, along with a large number of both known and\u003Cbr \/\u003E\nunknown system components. At the same time, an expanding arsenal of experimental tools can\u003Cbr \/\u003E\nconstrain models and directly test their predictions, making the modeling efforts not only\u003Cbr \/\u003E\nnecessary, but feasible [1].\n\u003C\/p\u003E\n\u003Cp\u003EAs an example, we have formulated a mechanistic model to describe the pattern formation\u003Cbr \/\u003E\ncontrolled by the epidermal growth factor receptor (EGFR) network in the fruit fly, Drosophila\u003Cbr \/\u003E\nmelanogaster. This receptor network, which is used dozens of times throughout the\u003Cbr \/\u003E\ndevelopment of all animal species, has also been found to be active in multiple types of tumors,\u003Cbr \/\u003E\nand thus, pharmacological studies of EGFR inhibition are common [2]. In our system, the EGFR\u003Cbr \/\u003E\nligand, Spitz, is controlled by a negative feedback loop through a diffusible inhibitor, Argos,\u003Cbr \/\u003E\nwhich acts as a ligand sink [3]. We have shown that the model is consistent with previous\u003Cbr \/\u003E\nexperimental data, and that the negative feedback loop serves to impart robustness to the pattern\u003Cbr \/\u003E\n[4]. We have discovered that neither correct patterning, nor robustness, requires a finely-tuned\u003Cbr \/\u003E\ndynamic length scale of Argos action [5]. Therefore, we are currently conducting experiments,\u003Cbr \/\u003E\nto be used in conjunction with the model, to estimate values of biophysical parameters, such as\u003Cbr \/\u003E\nthe dynamic length scale of Argos. We expect further analysis of this\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Gregory T. Reeves presents \u003Cem\u003EInsights from Models of Developmental Pattern Formation\u003C\/em\u003E as part of ChBE\u0027s spring seminar series.","format":"limited_html"}],"field_summary_sentence":[{"value":"Gregory T. Reeves presents seminar"}],"uid":"27255","created_gmt":"2010-05-20 11:47:16","changed_gmt":"2016-10-08 01:51:37","author":"Josie Giles","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2007-02-14T15:00:00-05:00","event_time_end":"2007-02-14T16:00:00-05:00","event_time_end_last":"2007-02-14T16:00:00-05:00","gmt_time_start":"2007-02-14 20:00:00","gmt_time_end":"2007-02-14 21:00:00","gmt_time_end_last":"2007-02-14 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1240","name":"School of Chemical and Biomolecular Engineering"}],"categories":[],"keywords":[{"id":"1303","name":"chbe"},{"id":"1704","name":"chemical \u0026 biomolecular engineering"},{"id":"2437","name":"lecture"},{"id":"166896","name":"seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003EJosie Giles\u003C\/strong\u003E\u003Cbr \/\u003ESchool of Chemical \u0026amp; Biomolecular Engineering\u003Cbr \/\u003E\u003Ca href=\u0022http:\/\/www.gatech.edu\/contact\/index.html?id=jg234\u0022\u003EContact Josie Giles\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-2299\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}