{"559911":{"#nid":"559911","#data":{"type":"event","title":"PhD Proposal by John NIcosia","body":[{"value":"\u003Cp\u003EJohn Nicosia\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EPhD Proposal Presentation\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EDate\u003C\/strong\u003E: Tuesday August 16, 2016\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp; \u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETime\u003C\/strong\u003E: 1:00 PM\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ELocation:\u003C\/strong\u003E\u0026nbsp; EBB,\u0026nbsp;Children\u2019s Healthcare of Atlanta (CHOA) Seminar Room\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECo-Advisors:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EThomas Barker, PhD\u0026nbsp;(BME, University of Virginia)\u003C\/p\u003E\u003Cp\u003EWilbur Lam, MD, PhD\u0026nbsp;(BME, Georgia Institute of Technology\/Emory University)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EThesis Committee Members:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EAshley Brown, PhD\u0026nbsp;(BME, North Carolina State University\/UNC Chapel Hill)\u003C\/p\u003E\u003Cp\u003EPhilip Santangelo, PhD\u0026nbsp;(BME, Georgia Institute of Technology\/Emory University)\u003C\/p\u003E\u003Cp\u003EGabriel Kwong, PhD\u0026nbsp;(BME, Georgia Institute of Technology\/Emory University)\u003C\/p\u003E\u003Cp\u003EAlberto Fernandez-Nieves, PhD\u0026nbsp;(Physics, Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EDevelopment and Characterization of a Platelet-like Particle for Treatment of Chemotherapy- and Radiation-induced Thrombocytopenia\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EExcessive bleeding is a common complication of cancer patients. Often, chemotherapy or radiation treatment leads to ablation of bone marrow resulting in low platelet count, a condition known as thrombocytopenia. Platelets are a critical component of hemostasis. In addition to forming a platelet plug within seconds of vascular injury, they secrete soluble factors to bolster the coagulation process. Additionally, platelets bind and contract the polymerized fibrin fibers that comprise the nascent blood clot, reinforcing its mechanical integrity. Annually, about 2.2 million platelet doses are transfused in the United States. However, due to bacterial contamination (about 1 in every 1000 doses) and immunogenicity concerns, transfusion of donor platelets entails considerable risk to the recipient. The Barker lab has recently reported on the development of a platelet substitute consisting of an ultra-low crosslinked (ULC), highly deformable poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAm-AAc) microgel core functionalized with a fibrin-specific single-domain antibody fragment. These platelet-like particles (PLPs) were shown to augment clot formation \u003Cem\u003Ein vitro \u003C\/em\u003Eand slow bleeding in a rat femoral vein injury model. However, little is known about the ability of PLPs to effectively marginate to the vessel wall, a crucial behavior of native platelets that might offer a means of augmenting PLP efficacy. Furthermore, there exists a significant gap in knowledge regarding the biodistribution and circulation time of PLPs. This proposal aims to explore the effect of increasing crosslinking density on PLP margination in an endothelialized microfluidic device and investigate biodistribution using positron emission tomography-computed tomography (PET\/CT) in a mouse model of radiation-induced thrombocytopenia.\u003C\/p\u003E\u003Cp\u003E \u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Development and Characterization of a Platelet-like Particle for Treatment of Chemotherapy- and Radiation-induced Thrombocytopenia"}],"uid":"27707","created_gmt":"2016-08-08 08:43:11","changed_gmt":"2016-10-08 02:18:36","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-08-16T14:00:00-04:00","event_time_end":"2016-08-16T16:00:00-04:00","event_time_end_last":"2016-08-16T16:00:00-04:00","gmt_time_start":"2016-08-16 18:00:00","gmt_time_end":"2016-08-16 20:00:00","gmt_time_end_last":"2016-08-16 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}